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AZD-0156 (AZD0156)
ATMK (Ataxia Telangiectasia Mutated Kinase), a serine/threonine protein kinase, is upregulated in a variety of cancer cell types, and activated in response to DNA damage and plays a key role in DNA-strand repair. AZD-0156 (AZD0156) is an orally bioavailable small molecule inhibiting the kinase activity of ATM and ATM-mediated signaling, preventing DNA damage checkpoint activation, disrupting DNA damage repair, inducing tumor cell apoptosis, and leading to cell death in ATM-overexpressing tumor cells. In addition, AZD0156 also sensitizes tumor cells to chemo- and radiotherapy.
Catalog NO: CT-A0156
Synonym: AZD0156
CAS NO: 1821428-35-6
Mol. Formula: C26H31N5O3
MW: 461.6
** in vivo grade material, 99.9% Pure by HPLC. A recrystallized crystalline solid (pic attached), coming with a High-precision Elemental Analysis, Bulk stock. Ship within 1 day.