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AVN944
AVN-944 (VX-944) is an orally available, uncompetitive small molecule inhibitor of inosine monophosphate dehydrogenase (IMPDH), an enzyme catalyzing the rate limiting step in the biosynthesis of guanine nucleotides. As IMPDH is overexpressed in some cancer cells, particularly in hematological malignancies, thus inhibition of this enzyme will result in depletion of guanine nucleotide pools, cessation of DNA synthesis, cell cycle block at the Gr(1)/S interface and interference with cell division, and induction of apoptosis. The reduction in guanine nucleotide pools will also interfere with the ability of G-coupled proteins to act as intracellular signal transducers.
Catalog NO: CT-AVN944
Synonym: VX-944, AVN-944
CAS NO: 297730-17-7
Mol. Formula: C25H27N5O5•0.35H2O
MW: 483.8
** InVivoGrade, 99.5%-100% chemical and optical purity (by achiral and chiral HPLCs). White powder, A Single isomer (out of possible four). Bulk Stock! Same day shipping.