AVL-292 (Spebrutinib) - Chemietek

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Home > Kinase Inhibitors > BTK (Bruton's Tyrosine Kinase) > AVL-292 (Spebrutinib)

AVL-292 (Spebrutinib)

B-cell antigen receptor (BCR) signaling is required for tumor expansion and proliferation. Bruton's Tyrosine Kinase (BTK) is an essential element of the BCR signaling pathway, playing an important role in B lymphocyte development, activation, signaling, proliferation and survival. Inhibiting BTK blocks BCR signaling and is of therapeutic significance in the treatment of both of B cell-related hematological cancers (e.g. non-Hodgkin lymphoma (NHL) and B cell chronic lymphocytic leukemia (B-CLL), and autoimmune diseases (e.g. rheumatoid arthritis). AVL-292 is a potent, selective and orally bioavailable irreversible inhibitor of BTK with IC50 value at low nM, currently in clinical trials.

Catalog NO:	CT-AVL292
Synonym:	Spebrutinib, CC-292
CAS NO:	1202757-89-8
Mol. Formula:	C₂₂H₂₂FN₅O₃
MW:	423

** in vivo Quality Material. >98.5% Pure by HPLC (attached). Anhydrous, validated by a spot-on Elemental Analysis. Bulk stock (Discounted price for 0.2, 0.5, 1G, …). Same Day Shipping.

Pricing and OrderingTechnical Data

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NO	Size	Price	In Stock	Quantity
1	10 mg	$80.00	YES
2	50 mg	$250.00	YES
3	100 mg	$400.00	YES

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Solubility : Soluble in DMSO

Storage : Store at 0°C (short term), -20°C (long term), desiccated

Purity : >98.5% by HPLC

Original QC Data : HPLC-MS, ¹HNMR, and Quantitative Elemental Analysis

Please Pick Batch NO:

CHEMIETEK, AVL-292, Lot 01, NMR (2.2).pdf
CHEMIETEK, AVL-292, Lot 01, HPLC.pdf
AVL-292, Lot 01, Certificate of Analysis.pdf
AVL-292, Lot 01, Visual Appearance (Color).pdf

Robak T, et al, Tyrosine kinase inhibitors as potential drugs for B-cell lymphoid malignancies and autoimmune disorders. Expert Opin Investig Drugs. 2012 Jul;21(7):921-47.

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