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Home > Kinase Inhibitors > Syk (Spleen Tyrosine Kinase) > ASN-002 (Gusacitinib)

ASN-002 (Gusacitinib)

Gusacitinib (ASN-002) is a clinical-stage, orally available potent dual inhibitor of SYK (Spleen Tyrosine Kinase) and pan-JAK (Janus kinases) with IC50 values of 5-46 nM in biochemical assays. In mechanistic cell-based studies involving IgE and cytokine stimulations, ASN002 strongly suppressed the SYK and JAK family kinase signaling pathways measured as pLAT and pSTAT levels, respectively. The compound showed anti-proliferative activity in a broad panel of human cancer cell lines including DHL6, DHL4, OCI-LY10, H929, Pfeiffer, HT-1376, and Lovo, suggesting activity in both solid and hematological tumor types. In a multiple myeloma (H929) xenograft model, ASN002 exhibited significant efficacy in inhibiting tumor growth (>95%). It also significantly delayed the onset of hind limb paralysis in the human erythroleukemia (HEL) mouse model (Refs 1, 2).

Catalog NO:	CT-ASN002
Synonym:	Gusacitinib, ASN002
CAS NO:	1425381-60-7
Mol. Formula:	C₂₄H₂₈N₈O₂ • 0.8H₂O
MW:	474.9

** in vivo Quality Material. 99.9% Purity, a recrystallized pale yellow powder. Hydrate, validated with a spot-on quantitative elemental analysis. Bulk (Grams). Same Day Shipping.

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NO	Size	Price	In Stock	Quantity
1	10 mg	$120.00	YES
2	50 mg	$350.00	YES
3	100 mg	$550.00	YES

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Solubility : Refer to Certificate of Analysis

Storage : Refer to Certificate of Analysis

Purity : >99.5% by HPLC (at 214 and 254 nm)

Original QC Data : HPLC, MS, NMR, and Quantitative Elemental analysis Report

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ASN-002 (Gusacitinib), Lot 01, Certificate of Analysis.pdf
ASN-002, Lot 01, Visual Appearance.pdf

1. N. S. Rao, et al, ASN002: A Potent Dual SYK/JAK Inhibitor Currently in a Phase I/II Study Shows Strong Antitumor Activity in Preclinical Studies, Blood 2015 vol. 126 no. 23 4009

2. S. Reddy, et al. Abstract 792: ASN002: A novel dual SYK/JAK inhibitor with strong antitumor activity. AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA.

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