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ARS-1620 is a potent, and covalent specific inhibitor of KRAS G12C, inhibiting RAS signaling with an IC50 of 120 nM. Exhibits a half maximal G12C target engagement (TE50) at 0.3 uM and near complete engagement at 3.0 uM across a panel of cell lines harboring the mutant allele; achieves rapid and sustained in vivo target occupancy to induce tumor regression (ref. 1)
Catalog NO: CT-ARS1620
Synonym: ARS1620
CAS NO: 1698055-85-4
Mol. Formula: C21H17ClF2N4O2
MW: 430.8
** in vivo grade material. >99.5% by achiral and chiral HPLCs. The Validated Active Isomer (Atropisomer), with a spot-on Elemental Analysis. Bulk (Grams). Prompt.