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Home > PD-1/PD-L1 Checkpoint Inhibitors > ARB-272572

ARB-272572

ARB-272572 is a potent, cellular active PD-L1 inhibitor with an IC₅₀ value of 400 pM for inhibition of PD-1/PD-L1 cell signaling (HTRF assay). ARB-272572 inhibits the PD-1/PD-L1 axis by inducing cell surface PD-L1 dimerization followed by rapid internalization into the cytosol. In addition, ARB-272572 is the first small-molecule checkpoint inhibitor inducing T cell proliferative and IFNγ responses to HBV peptides (ref 1).

Catalog NO:	CT-ARB272
Synonym:	ARB272572
CAS NO:	2368182-63-0
Mol. Formula:	C32H36N6O4˖3/4H2O
MW:	582.2 (or refer to the Certificate of Analysis, batch-specific)

** in vivo Quality Material. >99% Pure by HPLC (Attached). Hydrous, verified by a spot-on high-precision Quantitative Microanalysis. Bulk stock! Same day shipping.

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NO	Size	Price	In Stock	Quantity
1	5 mg	$120.00	YES
2	25 mg	$370.00	YES

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Solubility : refer to Certificate of Analysis

Storage : refer to Certificate of Analysis

Purity : >99% by HPLC

Original QC Data : HPLC, NMR, and Quantitative Elemental Analysis Report

Please Pick Batch NO:

ARB-272572 Lot 01 Certificate of Analysis.pdf

1. J. J. Park, et al., Checkpoint inhibition through small molecule-induced internalization of programmed death-ligand 1. Nat Commun. 2021 Feb 22;12(1):1222.

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