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Apremilast
Apremilast is an orally available small molecule inhibitor of phosphodiesterase 4 (PDE4), an enzyme that breaks down cyclic adenosine monophosphate (cAMP). In inflammatory cells, PDE4 is the dominant enzyme responsible for this reaction. The resulting increase in cAMP levels down-regulates expression of a number of the pro-inflammatory factors such as tumor necrosis factor alpha (TNFα), interleukin 17, interleukin 23, and many others, and up-regulates the anti-inflammatory interleukin 10. It is being used clinically for the treatment of certain types of psoriasis and psoriatic arthritis.
Catalog NO: CT-APRE
Synonym: Otezla
CAS NO: 608141-41-9
Mol. Formula: C22H24N2O7S
MW: 460.5
** A snow-white crystalline powder (see attached picture), >99.5% chemical and optical Purity, + impeccable 1H-NMR + clean Quantitative Elemental Analysis. Bulk Stock from Indianapolis USA.