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AMG-510 (Sotorasib) is an orally available, potent and irreversible KRAS G12C inhibitor, selectively targeting the KRAS p.G12C mutant, at either the DNA, RNA or protein level, and preventing, through a yet-to-be elucidated mechanism, expression of and/or tumor cell signaling through the KRAS p.G12C mutant. It is currently in clinical evaluation, as both a monotherapy and in combination with other targeted and immune therapies, to treat mutated KRAS protein related solid tumors.
Catalog NO: CT-AMG510
Synonym: Sotorasib, AMG510
CAS NO: 2252403-56-6
Mol. Formula: C30H30F2N6O3
MW: 560.6
** in vivo Quality Material. A single isomer. >99% by Achiral and Chiral HPLCs (Attached). The Validated Active Isomer (Atropisomer) (Cellular IC50 = 3-4 nM*, Validated), with a spot-on Quantitative Elemental Analysis. Bulk (Grams). Prompt.