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Navtemadlin (AMG-232) is a highly potent MDM2 inhibitor (SPR KD = 0.045 nM, SJSA-1 EdU IC50 = 9.1 nM), with remarkable pharmacokinetic properties and in vivo antitumor activity in the SJSA-1 osteosarcoma xenograft model (ED50 = 9.1 mg/kg), and is currently in clinical evaluations.
Catalog NO: CT-AMG232
Synonym: Navtemadlin, AMG232
CAS NO: 1352066-68-2
Mol. Formula: C28H35Cl2NO5S
MW: 568.6 (or, refer to Certificate of Analysis, batch-specific)
** in vivo Quality Material. >99.5% Pure by Achiral and Chiral HPLCs (attached), Snow-White Powder. 1/5 Hydrate, Validated by a spot-on Quantitative Elemental Analysis. Bulk (Discounted price for 0.5, 1, 2G, …). Same day shipping.