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AMG-232
AMG-232 (AMG 232) is an extremely potent MDM2 inhibitor (SPR KD = 0.045 nM, SJSA-1 EdU IC50 = 9.1 nM), with remarkable pharmacokinetic properties and in vivo antitumor activity in the SJSA-1 osteosarcoma xenograft model (ED50 = 9.1 mg/kg), and is currently in clinical evaluations.
Catalog NO: CT-AMG232
Synonym: AMG 232
CAS NO: 1352066-68-2
Mol. Formula: C28H35Cl2NO5S ∙ 0.6Na
MW: 582.3
** A snow-white crystalline powder (see attached picture), 98.7% chemical purity (by HPLC), >99.5% stereomeric purity (e.e, d.e) (by Chiral HPLC), + clean 1H-NMR, coming with a Quantitative Elemental Analysis. Ship within 1 day.