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AMG-176 (AMG176)
AMG 176 is an orally bioavailable, highly potent and selective Mcl-1 inhibitor, binding reversibly to BH3- groove of the protein with a Ki value in picomolar range. Demonstrate in vitro and in vivo antitumor efficacy in Mcl-1 dependent cancer models. It is currently in clinical evaluation for the treatment of hematologic malignancies.
Catalog NO: CT-AMG176
Synonym: AMG176
CAS NO: 1883727-34-1
Mol. Formula: C33H41ClN2O5S
MW: 613.2
** in vivo Grade Material. 99.8-100% chemically & stereomerically pure by achiral and chiral HPLCs (attached), w/ validated picomolar binding potency. Good for i. v. Administration. In stock. Prompt.