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AG-221 (Enasidenib)
AG-221 (Enasidenib) is a first-in-class, orally available, selective, potent inhibitor of mutant IDH2 (Isocitrate dehydrogenase type 2). It specifically inhibits IDH2 in the mitochondria, blocking the formation of oncometabolite 2-hydroxyglutarate (2HG). In in vitro studies, AG-221 reduced 2-HG levels by >90%, reversed histone and DNA hypermethylation, and induced cellular differentiation in leukemia cell models.
Catalog NO: CT-AG221
Synonym: Enasidenib, CC-90007
CAS NO: 1446502-11-9
Mol. Formula: C19H17F6N7O
MW: 473.4
** 99.9% Purity. in vivo Grade Quality. Snow-white powder. Clean and impeccable (see attached QC Docs), with a spot-on Microanalysis. Bulk stock! Same day shipping.