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IDH (Isocitrate Dehydrogenase) Inhibitors
IMPDH (Inosine Monosphosphate Dehydrogenase) Inhibitor
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Reagents for Biological Assays
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SMAC Mimics and Inhibitors of IAP
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Akt/(PKB (Protein Kinase B)
ALK (Anaplastic Lymphoma Kinase)
AMPK (AMP-Activated Protein Kinase)
ASK1 (Apoptosis Signal-regulating Kinase 1)
ATM (Ataxia Telangiectasia Mutated Kinase)
ATR (Ataxia Telangiectasia and Rad3 Related)
Aurora Kinase
Aurora A Kinase Selective
Aurora B Kinase Selective
Aurora C Kinase Selective
AXL (AXL Receptor Tyrosine Kinase)
Bcr-Abl/c-kit/PDGFR/Src
BTK (Bruton's Tyrosine Kinase)
BUB1 (Budding Uninhibited by Benzimidazoles 1)(Mitotic checkpoint serine/threonine-protein kinase)
CDC7 (Cell Division Cycle 7-related Protein Kinase)
CDK (Cyclin-dependent Kinase)
CDK2 Selective
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ErbB
Erk (Extracellular signal regulated kinase)
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FGFR (Fibroblast Growth Factor Receptor)
FGFR4 Specific
FLT3 (Fms-like Tyrosine Kinase 3)
IGF-1R
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JAK3 Selective
LRRK2
MEK/MAPK
Mps1 (Monopolar Spindle 1)
mTOR
NIK (NF-κB-inducing kinase) Inhibitors
P21-Activated Kinases
P70S6K (Ribosomal Protein S6 Kinase)
PDGFR
PDK1
PI3K - p110 Alpha (α) Specific
PI3K - p110 Beta (β) Specific
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PI3K - Pan
PI3K/mTOR
PIM
PKC (Protein Kinase C)
PKMYT1
PLK (Polo-like kinase)
PLK1 (Polo-like Kinase 1) Selective
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PTEF-b/CDK9
RAF (Rapidly Accelerated Fibrosarcoma)
RET (Rearranged During Transfection) Kinase
RIP1 (Receptor Interacting Protein 1) Kinase
ROCK (Rho-Associated Protein Kinase)
ROS1 (Proto-oncogene Tyrosine-protein Kinase ROS)
Syk (Spleen Tyrosine Kinase)
TGFβ (Transforming Growth Factor Beta (TGFβ) Receptor) Kinase
TOPK (T–lymphokine-activated killer cell–originated protein kinase)
TRK (Tropomyosin Receptor Kinase) (Tyrosine Receptor Kinase)
TTK (Human Protein Kinase Monopolar Spindle 1 (hMps1))
VEGFR
WEE1
Factor VIIa inhibitor
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CLK (CDC2-like-Kinase)
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PKMYT1 Kinase Inhibitor
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TTK (Human Protein Kinase Monopolar Spindle 1 (hMps1))
Tubulin
Wee1
Monocarboxylate Transporter 1 (MCT 1) Inhibitor
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DNMT1 (DNA Methyltransferase 1) inhibitor
DOT1L Methyltransferase Inhibitor
EP300/CBP HAT (Histone Acetyltransferases) Inhibitor
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EZH2 (Mutant) METHYLTRANSFERASE INHIBITOR
HDAC (histone deacetylase) Inhibitors
HDAC1-Specific Inhibitors
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HDAC6-Specific Inhibitors
Lysine specific demethylase 1 (LSD1) Inhibitor
Menin-MLL interaction inhibitors
PRC2 (the catalytic subunit of polycomb repressive complex 2)
PRMT5 (Protein Arginine Methyltransferase 5) Inhibitors/Modulators
PRMTs (Type I) Inhibitors/Modulators
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Angiotensin II receptor (AT1)
Endothelin receptor antagonist (type A specific)
Heat Shock Proteins HSP90 Inhibitors
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HMG-CoA reductase inhibitor
Androgen receptor
Glucocorticoid Receptor
RXRs (retinoid X receptors)
Autotaxin Inhibitor
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PDE4 ( phosphodiesterase type 4)
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IMPDH Inhibitor
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STING (STIMULATOR OF INTERFERON GENES) AGONIST
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Anti-angiogenesis
Anti-fibrosis
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Arginase Inhibitor
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Prostanoid ligand
RIP1 (RECEPTOR INTERACTING PROTEIN 1) KINASE
TGFβ Kinase Inhibitor
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CD73 (ecto-5'-nucleotidase) Inhibitor
CBP/β-catenin Modulators
CoreDAC Inhibitors
IDO1 (Indoleamine 2,3-dioxygenase 1) Inhibitor
IKZF1/3 (Zinc Finger Protein 1/3)
Immunoproteasome Inhibitor
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mTOR inhibitors
PD-1/PD-L1 CHECKPOINT INHIBITORS
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PTPN2/N1 (Protein Tyrosine Phosphatase Non-Receptor Type 2/1) Inhibitors
RORγ (Retinoic Acid-related Orphan Receptor gamma (γ )) Agonist
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Topoisomerase II
Kinesin (CENP-E) Inhibitor
G12C Mutant Inhibitors
G12D Mutant Inhibitors
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SOS1 Inhibitors
Tri-complex KRASG12C (ON) Inhibitor
Tri-complex KRAS inhibitors
Arginase Inhibitor
Glutaminase Inhibitor
IDH (Isocitrate Dehydrogenase) Inhibitors
IMPDH (Inosine Monosphosphate Dehydrogenase) Inhibitor
MAT2A Inhibitor
Monocarboxylate Transporter 1 (MCT 1) Inhibitor
Monocarboxylate Transporter 4 (MCT 4)
OXPHOS (Mitochondrial Oxidative Phosphorylation of Complex I) Modulator
Monocarboxylate Transporter 1 (MCT 1) Inhibitor
MTH1
Neuroactive/BBB Penetrant
Orexin Receptor Antagonists
SDAM (Serotonin-Dopamine Activity Modulator)
TRK (Tropomyosin Receptor Kinase)(Tyrosine Receptor Kinase) Inhibitor
CBP/β-catenin Modulators
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Oxidoreductase Inhibitor
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Thymidylate synthase inhibitor
p53–MDM2 Interaction Inhibitor
p53 Reactivator
PTPN2/N1 (Protein Tyrosine Phosphatase Non-Receptor Type 2/1) Inhibitors
SHP2 Phosphatase Inhibitor
Wip1 Phosphatase Inhibitor
PARP (Poly (ADP-ribose) polymerase)
Stem cell research
NADD8-Activating Enzyme Inhibtor
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Ubiquitin-Activating Enzyme Inhibitor
USP1 (Ubiquitin Specific Protease 1)
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AXL (AXL Receptor Tyrosine Kinase)
Bcr-Abl/c-kit/PDGFR/Src
BTK (Bruton's Tyrosine Kinase)
BUB1 (Budding Uninhibited by Benzimidazoles 1)(Mitotic checkpoint serine/threonine-protein kinase)
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CLK2 (CDC2-like Kinase 2)
c-Met
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ErbB
Erk (Extracellular signal regulated kinase)
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FGFR4 Specific
FLT3 (Fms-like Tyrosine Kinase 3)
IGF-1R
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PDGFR
PDK1
PI3K - p110 Alpha (α) Specific
PI3K - p110 Beta (β) Specific
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PI3K - p110 Gamma (γ) Specific
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PI3K/mTOR
PIM
PKC (Protein Kinase C)
PKMYT1
PLK (Polo-like kinase)
PLK1 (Polo-like Kinase 1) Selective
PLK4 (Polo-like Kinase 4) Selective
PTEF-b/CDK9
RAF (Rapidly Accelerated Fibrosarcoma)
RET (Rearranged During Transfection) Kinase
RIP1 (Receptor Interacting Protein 1) Kinase
ROCK (Rho-Associated Protein Kinase)
ROS1 (Proto-oncogene Tyrosine-protein Kinase ROS)
Syk (Spleen Tyrosine Kinase)
TGFβ (Transforming Growth Factor Beta (TGFβ) Receptor) Kinase
TOPK (T–lymphokine-activated killer cell–originated protein kinase)
TRK (Tropomyosin Receptor Kinase) (Tyrosine Receptor Kinase)
TTK (Human Protein Kinase Monopolar Spindle 1 (hMps1))
VEGFR
WEE1
Activated Factor VII (Factor VIIa)
Factor VIIa inhibitor
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CBP/β-catenin Modulators
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CLK (CDC2-like-Kinase)
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IMPDH Inhibitor
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p53-MDM2 Interaction Inhibitor
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PRC2 (the catalytic subunit of polycomb repressive complex 2) >
PKMYT1 Kinase Inhibitor
SMAC Mimics and Inhibitors of IAP
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TTK (Human Protein Kinase Monopolar Spindle 1 (hMps1))
Tubulin
Wee1
Cell Metabolism Modulators
Monocarboxylate Transporter 1 (MCT 1) Inhibitor
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Chemotherapy Agents
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DNA Repair Targeted Therapy
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BET Family Protein Inhibitors
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BET Bromodomain II (BDII) Selective Inhibitors
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CBP/P300 Bromodomain Inhibitor
CoreDAC Inhibitors
DNMT1 (DNA Methyltransferase 1) inhibitor
DOT1L Methyltransferase Inhibitor
EP300/CBP HAT (Histone Acetyltransferases) Inhibitor
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EZH2 (Mutant) METHYLTRANSFERASE INHIBITOR
HDAC (histone deacetylase) Inhibitors
HDAC1-Specific Inhibitors
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HDAC6-Specific Inhibitors
Lysine specific demethylase 1 (LSD1) Inhibitor
Menin-MLL interaction inhibitors
PRC2 (the catalytic subunit of polycomb repressive complex 2)
PRMT5 (Protein Arginine Methyltransferase 5) Inhibitors/Modulators
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Endothelin receptor antagonist (type A specific)
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HMG-CoA reductase inhibitor
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IDH (Isocitrate Dehydrogenase) Inhibitors
Mutant-IDH1 Inhibitor
Mutant-IDH2 Inhibitor
IMPDH (Inosine Monosphosphate Dehydrogenase) Inhibitor
IMPDH Inhibitor
Immune Activation Agents/Modulators
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Immuno/Inflammatory Mediators
Anti-angiogenesis
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Arginase Inhibitor
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IKZF1/3 (Zinc Finger Protein 1/3)
Immunoproteasome Inhibitor
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mTOR inhibitors
PD-1/PD-L1 CHECKPOINT INHIBITORS
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Tri-complex KRAS inhibitors
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Metabolic Pathway Modulators
Arginase Inhibitor
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IDH (Isocitrate Dehydrogenase) Inhibitors
IMPDH (Inosine Monosphosphate Dehydrogenase) Inhibitor
MAT2A Inhibitor
Monocarboxylate Transporter 1 (MCT 1) Inhibitor
Monocarboxylate Transporter 4 (MCT 4)
OXPHOS (Mitochondrial Oxidative Phosphorylation of Complex I) Modulator
Monocarboxylate Transporter 1 (MCT 1) Inhibitor/Ligand
Monocarboxylate Transporter 1 (MCT 1) Inhibitor
Monocarboxylate Transporter 4 (MCT 4) Inhibitor
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MTH1
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SDAM (Serotonin-Dopamine Activity Modulator)
TRK (Tropomyosin Receptor Kinase)(Tyrosine Receptor Kinase) Inhibitor
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CBP/β-catenin Modulators
Gamma (γ) Secretase (GS) Inhibitors
Notch Signaling Inhibitors
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CRM1 (exportin 1) Inhibitor(s)
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HCV Protease Inhibitor
HIV-1 integrase Inhibitor
Oxidoreductase Inhibitor
P-p68 (Phosphorylated-p68 RNA Helicase) Inhibitor
Thymidylate synthase inhibitor
OXPHOS (Mitochondrial Oxidative Phosphorylation of Complex I) Modulator
PD-1/PD-L1 Checkpoint Inhibitors
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p53–MDM2 Interaction Inhibitor
p53 Reactivator
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SHP2 Phosphatase Inhibitor
Wip1 Phosphatase Inhibitor
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PPARG Agonist (Peroxisome Proliferator-activated Receptor Gamma Agomist)
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ABBV-467
ABBV-467
ABBV-467 is a highly potent and selective MCL-1 inhibitor (Ki < 0.01nM). ABBV-467 induces tumor regression in xenograft models of MM and AML when combined with Venetoclax (ref. 1).
Catalog NO:
CT-ABBV467
Synonym:
ABBV467
CAS NO:
2287186-66-5
Mol. Formula:
C53H51Cl2FN6O9S
MW:
1308.0
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5 mg
$300.00
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10 mg
$450.00
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50 mg
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Solubility :
Refer to Certificate of Analysis
Storage :
Refer to Certificate of Analysis
Purity :
99% by Achiral and Chiral HPLCs
Original QC Data :
Achiral and Chiral HPLCs, NMR, and Quantitative Elemental Analysis Report
There is no COA file for this product
1. Yuda J, et al, Selective MCL-1 inhibitor ABBV-467 is efficacious in tumor models but is associated with cardiac troponin increases in patients. Commun Med (Lond). 2023 Oct 25;3(1):154.
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