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Home > Bcl-2 Protein Inhibitors/Degraders > MCL-1 Selective Inhibitors > S64315

S64315

S64315 (MIK665) is a clinical-stage, BH3-Groove binding Mcl-1 inhibitor, potently and selectively binding to the protein target with Ki in picomolar range. Demonstrate in vitro and in vivo antitumor efficacy in Mcl-1 dependent cancer models. Achieve superior activity and enhanced solid tumor response when applied in combination with Bcl-2 inhibitors such as ABT-199/Venetoclax (Our Prod No. CT-A199), and BCL-201/S55746 (Our Prod No. CT-BCL201) (refs. 1, 2).

Catalog NO:	CT-MIK665
Synonym:	NVP-MIK665, MIK-665, S-64315
CAS NO:	1799631-75-6
Mol. Formula:	C47H44ClFN6O6S∙H2O
MW:	893.4 (refer to the certificate of analysis, batch-specific)

** in vivo Quality Material, Good for i.v. Administration. 99.9-100% by achiral and chiral HPLCs. A single isomer (atropisomer) (out of possible four) (ref. 3a). Monohydrate, validated by a spot-on Microanalysis. Validated potency (IC50<1 nM) (ref. 3b).

Pricing and OrderingTechnical Data

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NO	Size	Price	In Stock	Quantity
1	5mg	$175.00	YES
2	10mg	$250.00	YES
3	50 mg	$850.00	YES

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Solubility : Refer to Certificate of Analysis

Storage : Refer to Certificate of Analysis

Purity : 99.9-100% Chemically, Atropisomerically and Enantiomerically Pure by achiral and chiral HPLCs

Original QC Data : Achiral and Chiral HPLCs, MS, NMR, and Elemental Analysis Report

Please Pick Batch NO:

MIK665 (S-64315), Lot 02, Certificate of Analysis.pdf
MIK665 (S64315), lot 02, Visual Appearance.pdf
C_K, S64315, Lot 02, Achiral HPLC,.pdf
C_K, S64315, Lot 02, Chiral HPLC, (2).pdf
C_K, S64315, Lot 02, NMR, d4-MeOH (1-3).pdf

1. E. Halilovic, et al, MIK665/S64315, a novel Mcl-1 inhibitor, in combination with Bcl-2 inhibitors exhibits strong synergistic antitumor activity in a range of hematologic malignancies [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4477.

2. Z. Szlavik, et al, Discovery of S64315, a Potent and Selective Mcl-1 Inhibitor, J Med Chem, 2020 Nov 25;63(22):13762-13795

3. a. Verified by Chiral HPLC; b. Binding potency (IC50 = 0.7 nM) was measured for its ability to displace BAK peptide from Mcl1-BAK complex.

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