NVP-LDE225 Diphosphate salt (Erismodegib, Sonidegib) - Chemietek

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Home > Hedgehog Signaling Pathway Modulators > Hedgehog Signaling Pathway Inhibitors > NVP-LDE225 Diphosphate salt (Erismodegib, Sonidegib)

NVP-LDE225 Diphosphate salt (Erismodegib, Sonidegib)

A potent, selective, and orally bioavailable Smoothened (Hedgehog Signaling Pathway) antagonist, currently in clinical trials. Diphosphate salt offers a much better bioavailability than free base (Ref. 1)

Catalog NO:	CT-LDE225
Synonym:	Erismodegib, Sonidegib
CAS NO:	1218778-77-8
Mol. Formula:	C₂₆H₂₆F₃N₃O₃ ∙ 2H₃PO₄
MW:	681.5

** in vivo Quality Material. Snow-white crystalline powder. clean (99.9% pure) & impeccable. ChemieTek offers the product as a diphosphate salt,* a formulation with a superior bioavailability to free base. Bulk Stock!! Same day shipping.

Pricing and OrderingTechnical Data

QC & Certificates

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NO	Size	Price	In Stock	Quantity
1	10 mg	$85.00	YES
2	50 mg	$200.00	YES
3	100 mg	$325.00	YES
4	200 mg	$575.00	YES

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Solubility : Soluble in DMSO

Storage : Store at 0°C (short term), -20°C (long term), desiccated

Purity : 99.9% (HPLC at 214 and 254 nm)

Original QC Data : HPLC, ¹HNMR and Quantitative Elemental Analysis Report

Please Pick Batch NO:

NVP-LDE225, Lot 06, Certificate of Analysis.pdf
NVP-LDE225, Lot 06,Visual Appearance.pdf

1. Pan, S., et al, Discovery of NVP-LDE225, a Potent and Selective Smoothened Antagonist, ACS Med. Chem. Lett., 2010, 1 (3), pp 130–134.

*2.0 equivalent phosphate is confirmed by a spot-on Quantitative Elemental Analysis - the most rigorous standard, achieved ONLY by Chemietek. This product is functionally equivalent to the very same material from Novartis (The drug developer) per our clients.

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