GSK-1070916 (NMI-900) - Chemietek

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Home > Kinase Inhibitors > Aurora Kinase > GSK-1070916 (NMI-900)

GSK-1070916 (NMI-900)

GSK1070916 is a potent, selective and ATP competitive inhibitor of Aurora B and C kinases with Ki values of 0.38 and 1.5 nM, respectively, and is highly selective over Aurora A (Ki = 490 nM). Its inhibition of Aurora B and C is time-dependent, with an enzyme-inhibitor dissociation half-life of >480 min and 270 min respectively, a unique feature compared to other Aurora B Kinase inhibitors under clinical development. It is selective over other kinase targets with an exception of of FLT1, TIE2, SIK, FLT4, and FGFR1 (with IC50 values of 42, 59, 70, 74, and 78 nM, respectively). It is currently in clinical development.

Catalog NO:	CT-GSK107
Synonym:	NMI-900
CAS NO:	942918-07-2
Mol. Formula:	C₃₀H₃₃N₇O • H₂O
MW:	525.6

** in vivo Quality Material. >99.5% Pure by HPLC. Recrystallized white powder. Monohydrate, validated by a spot-on Elemental Analysis. Make for in vivo studies. Bulk Stock. Prompt.

Pricing and OrderingTechnical Data

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References

NO	Size	Price	In Stock	Quantity
1	5 mg	$100.00	YES
2	10 mg	$150.00	YES
3	50 mg	$360.00	YES
4	100 mg	$620.00	YES
5	200 mg	$1,100.00	YES

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Solubility : In DMSO

Storage : Store at 0°C (short term), -20°C (long term), desiccated

Purity : >99.5% (HPLC at 214 and 254 nm)

Original QC Data : HPLC-MS, ¹HNMR, and Quatitative Elemental Analysis

Please Pick Batch NO:

GSK1070916, Lot 01, 1xH2O, COA.pdf
GSK1070916, Lot 01, Appearance.pdf

1. N. D. Adams, et al., Discovery of GSK1070916, a Potent and Selective Inhibitor of Aurora B/C Kinase, J. Med. Chem., 2010, 53 (10), pp 3973–4001

1. K. Anderson, et al, Biochemical characterization of GSK1070916, a potent and selective inhibitor of Aurora B and Aurora C kinases with an extremely long residence time, Biochem. J. (2009) 420 (259–265)

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