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Home > Kinase Inhibitors > CDK (Cyclin-dependent Kinase) > Dinaciclib

Dinaciclib

Dinaciclib (SCH 727965) is a potent and selective CDK inhibitor and a novel cytotoxic agent. It inhibits CDK2, CDK5, CDK1, and CDK9 activity in vitro with IC50 values of 1, 1, 3, and 4 nM, respectively. It exhibits superior activity, compared with flavopiridol, with a much improved therapeutic index. It is currently in clinical trials.

Catalog NO:	CT-DINA
Synonym:	SCH 727965, SCH727965
CAS NO:	779353-01-4
Mol. Formula:	C₂₁H₂₈N₆O₂ ∙ 1/2 H₂O
MW:	405.5

** in vivo Grade Material, >99.5% by achiral and chiral HPLCs. A recrystallized beige powder (pic attached), clean & impeccable 1H-NMR, Hemihydrate, validated by a spot-on Quantitative Elemental Analysis. Bulk stock. Prompt.

Pricing and OrderingTechnical Data

QC & Certificates

References

NO	Size	Price	In Stock	Quantity
1	10 mg	$100.00	YES
2	50 mg	$260.00	YES
3	100 mg	$380.00	YES
4	200 mg	$650.00	YES

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Solubility : Soluble in DMSO

Storage : Store at 0°C (short term), -20°C (long term), desiccated

Purity : >99.5% Chem and Optical Purity by achiral and chiral HPLCs.

Original QC Data : HPLC-MS, ¹HNMR, Chiral HPLC, and Quantitative Elemental Analysis report

Please Pick Batch NO:

Dinaciclib, Lot 03, Certificate of Analysis.pdf
Dinaciclib, Lot 03, Visual Appearance.pdf
C_K, Dinaciclib, Lot 03, Achiral HPLC.pdf
C_K, Dinaciclib, Lot 03, Chiral HPLC.pdf
C_K, Dinaciclib, Lot 03, NMR, d4-MeOH, (1-2).pdf

1. D. Parry, et al, Dinaciclib (SCH 727965), a Novel and Potent Cyclin-Dependent Kinase Inhibitor, Mol Cancer Ther, 2010, 9(8); 2344–53

2. K. Paruch, et al, Discovery of Dinaciclib (SCH 727965): A Potent and Selective Inhibitor of Cyclin-Dependent Kinases, ACS Med. Chem. Lett., 2010, 1 (5), pp 204–208

3. G. Feldmann, et al, Cyclin-dependent kinase inhibitor Dinaciclib (SCH727965) inhibits pancreatic cancer growth and progression in murine xenograft models, Cancer Biol. Ther. 2011, 12(7), 598-609

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