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Adenosine Receptor Ligands

Angiotensin II receptor (AT1)

Endothelin receptor antagonist (type A specific)

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HMG-CoA reductase inhibitor

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Autotaxin Inhibitor

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Mutant-IDH1 Inhibitor

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IMPDH Inhibitor

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Liver X receptor (LXR) Agonist/Modulator

RORγ (Retinoic Acid-related Orphan Receptor gamma (γ )) Agonist

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Toll-like Receptor Agonist

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Anti-angiogenesis

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Arginase Inhibitor

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Prostanoid ligand

RIP1 (RECEPTOR INTERACTING PROTEIN 1) KINASE

TGFβ Kinase Inhibitor

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Adenosine 2A Receptor Antagonist

Arginase Inhibitor

CD73 (ecto-5'-nucleotidase) Inhibitor

CBP/β-catenin Modulators

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IDO1 (Indoleamine 2,3-dioxygenase 1) Inhibitor

IKZF1/3 (Zinc Finger Protein 1/3)

Immunoproteasome Inhibitor

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mTOR inhibitors

PD-1/PD-L1 CHECKPOINT INHIBITORS

PI3Kγ (GAMMA) Specific Inhibitors

PTPN2/N1 (Protein Tyrosine Phosphatase Non-Receptor Type 2/1) Inhibitors

RORγ (Retinoic Acid-related Orphan Receptor gamma (γ )) Agonist

SHP2 Phosphatase Inhibitor

STING (Stimulator of Interferon Genes) Agonist

SUMOylation Inhibitor

TGFβ Kinase Inhibitor

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Topoisomerase I

Topoisomerase II

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Kinesin (CENP-E) Inhibitor

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G12C Mutant Inhibitors

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KRAS-PDEδ Interaction Inhibitor

Pan-KRAS Inhibitors

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Tri-complex KRASG12C (ON) Inhibitor

Tri-complex KRAS inhibitors

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Arginase Inhibitor

Glutaminase Inhibitor

IDH (Isocitrate Dehydrogenase) Inhibitors

IMPDH (Inosine Monosphosphate Dehydrogenase) Inhibitor

MAT2A Inhibitor

Monocarboxylate Transporter 1 (MCT 1) Inhibitor

Monocarboxylate Transporter 4 (MCT 4)

OXPHOS (Mitochondrial Oxidative Phosphorylation of Complex I) Modulator

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Monocarboxylate Transporter 1 (MCT 1) Inhibitor

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Neuroactive/BBB Penetrant

Orexin Receptor Antagonists

SDAM (Serotonin-Dopamine Activity Modulator)

TRK (Tropomyosin Receptor Kinase)(Tyrosine Receptor Kinase) Inhibitor

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CBP/β-catenin Modulators

Gamma (γ) Secretase (GS) Inhibitors

Notch Signaling Inhibitors

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CRM1 (exportin 1) Inhibitor(s)

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HCV Protease Inhibitor

HIV-1 integrase Inhibitor

Oxidoreductase Inhibitor

P-p68 (Phosphorylated-p68 RNA Helicase) Inhibitor

Thymidylate synthase inhibitor

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p53–MDM2 Interaction Inhibitor

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PTPN2/N1 (Protein Tyrosine Phosphatase Non-Receptor Type 2/1) Inhibitors

SHP2 Phosphatase Inhibitor

Wip1 Phosphatase Inhibitor

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PARP (Poly (ADP-ribose) polymerase)

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Stem cell research

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NADD8-Activating Enzyme Inhibtor

Proteasome Inhibitor

SUMOylation Inhibitor

Ubiquitin-Activating Enzyme Inhibitor

USP1 (Ubiquitin Specific Protease 1)

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Home > Hydrolase Inhibitors/Modulators > PDE4 ( phosphodiesterase type 4) > Apremilast

Apremilast

Apremilast is an orally available small molecule inhibitor of phosphodiesterase 4 (PDE4), an enzyme that breaks down cyclic adenosine monophosphate (cAMP). In inflammatory cells, PDE4 is the dominant enzyme responsible for this reaction. The resulting increase in cAMP levels down-regulates expression of a number of the pro-inflammatory factors such as tumor necrosis factor alpha (TNFα), interleukin 17, interleukin 23, and many others, and up-regulates the anti-inflammatory interleukin 10. It is being used clinically for the treatment of certain types of psoriasis and psoriatic arthritis.

Catalog NO:	CT-APRE
Synonym:	Otezla
CAS NO:	608141-41-9
Mol. Formula:	C22H24N2O7S
MW:	460.5

** A snow-white crystalline powder (see attached picture), >99.5% chemical and optical Purity, + impeccable 1H-NMR + clean Quantitative Elemental Analysis. Bulk Stock from Indianapolis USA.

Pricing and OrderingTechnical Data

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NO	Size	Price	In Stock	Quantity
1	10 mg	$130.00	YES
2	50 mg	$230.00	YES
3	100 mg	$350.00	YES

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Solubility : Refer to Certificate

Storage : Refer to Certificate

Purity : >99.5% chemical and optical purity by HPLC and chiral HPLC

Original QC Data : HPLC, 1H-NMR, chiral HPLC, and quantitative elemental analysis report

Please Pick Batch NO:

Apremilast, Lot 01, Certificate of Analysis.pdf
Apremilast, Lot 01, Visual Appearance.pdf

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