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MIK665 (S64315)
MIK665 (S-64315) is a clinical-stage, BH3-Groove binding Mcl-1 inhibitor, potently and selectively binding to the protein target with Ki in picomolar range. Demonstrates in vitro and in vivo antitumor efficacy in Mcl-1 dependent cancer models. Achieves superior activity and enhanced solid tumor response when applied in combination with Bcl-2 inhibitors such as ABT-199/Venetoclax (Our Prod No. CT-A199), and BCL-201/S55746 (Our Prod No. CT-BCL201) (ref. 1).
Catalog NO: CT-MIK665
Synonym: NVP-MIK665, MIK-665, S-64315
CAS NO: 1799631-75-6
Mol. Formula: C47H44ClFN6O6S∙H2O
MW: 893.4 (refer to the certificate of analysis, batch-specific)
** in vivo Grade Quality, Good for i.v. Administration. 99.9-100% by achiral and chiral HPLCs. A single isomer (atropisomer) (out of possible four) (ref. 2a). Monohydrate, validated by Microanalysis + Validated potency (IC50<1 nM) (ref. 2b)