Welcome visitor Log In - or - Register
(
0 items /
$0.00
)
View Cart
Check Out
four ways
Quick Search:
Doxorubicin
Doxorubicin hyrdrochloride is an anthracycline antibiotic with antineoplastic activity. Doxorubicin, isolated from the bacterium Streptomyces peucetius var. caesius, is the hydroxylated congener of daunorubicin. Doxorubicin intercalates between base pairs in the DNA helix, thereby preventing DNA replication and ultimately inhibiting protein synthesis. Additionally, doxorubicin inhibits topoisomerase II which results in an increased and stabilized cleavable enzyme-DNA linked complex during DNA replication and subsequently prevents the ligation of the nucleotide strand after double-strand breakage. Doxorubicin also forms oxygen free radicals resulting in cytotoxicity secondary to lipid peroxidation of cell membrane lipids; the formation of oxygen free radicals also contributes to the toxicity of the anthracycline antibiotics, namely the cardiac and cutaneous vascular effects.
Catalog NO: CT-DOXO
Synonym: Adriamycin
CAS NO: 23214-92-8
Mol. Formula: C27H29NO11 ∙ HCl ∙ 0.5 x H2O
MW: 589
** 99% purity by HPLC, Coming with a high precision quantitative elemental analysis. Grams in stock from Indianapolis USA. Ship within 1 day.