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XL-147

XL-147 (Pilaralisib) is a potent, selective and orally bioavailable ATP-competitive small molecule inhibitor targeting pan-class I phosphatidylinositol 3 kinase (PI3K) family with IC50 values of 39, 383, 36 and 23 nM for p110 α, β, δ and γ isoforms, and is highly selective over mTOR (IC50 > 15000 nM), VPS34 (IC50 = 6975 nM), DNAPK (IC50 = 4750 nM). It is currently in clinical trials for cancer treatment.

Catalog NO:	CT-XL147
Synonym:	Pilaralisib, SAR245408
CAS NO:	934526-89-3
Mol. Formula:	C₂₅H₂₅ClN₆O₄S•0.5HCl
MW:	559.3

** Grams in stock from Indianapolis USA. Ship within 1 day. CHEMIETEK offers XL-147 (CAS No. 934526-89-3) with the authoritatively confirmed structure (Ref. 3).

Pricing and OrderingTechnical Data

QC & Certificates

References

NO	Size	Price	In Stock
1	10 mg	$120.00	YES
2	50 mg	$260.00	YES
3	100 mg	$400.00	YES
4	200 mg	$700.00	YES

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Solubility : Soluble in DMSO

Storage : Store at 0°C (short term), -20°C (long term), desiccated

Purity : >99% (HPLC at 214 and 254 nm)

Original QC Data : HPLC-MS, ¹HNMR, Microanalysis (Elemental Analysis)

Please Pick Batch NO:

XL-147, Current Lot, Certificate of Analysis

1. GI Shapiro, et al., Phase I safety, pharmacokinetic, and pharmacodynamic study of SAR245408 (XL147), an oral pan-class I PI3K inhibitor, in patients with advanced solid tumors. Clin Cancer Res. 2014 Jan 1;20(1):233-45. doi: 10.1158/1078-0432.CCR-13-1777.

2. CP Reynolds, et al., Initial testing (stage 1) of the phosphatidylinositol 3' kinase inhibitor, SAR245408 (XL147) by the pediatric preclinical testing program. Pediatr Blood Cancer, 2013 May; 60(5):791-8. doi: 10.1002/pbc.24301.

3. L. Debussche, et al, Compositions comprising a pi3k inhibitor and a mek inhibitor and their use for treating cancer, EP 2648729 A1 (text from WO2012078832A1)

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