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VX-11e
Extracellular signal regulated kinase (ERK) is a pivotal enzyme in the pathway downstream of Ras, Raf, and MEK, acting as a central link between multiple signaling pathways. VX-11e (or ERK 11e) is a potent, selective, and orally bioavailable inhibitor of ERK2 with Ki < 2 nM, exhibiting potent cellular activity (IC50=48 nM in an HT29 cell proliferation assay). It is highly selective against a panel of more than 140 other kinases - most notably, GSK3 (Ki = 400nM), AURA (Ki = 540nM), CDK2 (Ki = 850nM), FLT3 (Ki = 1400nM), ROCK1 (Ki = 1400nM), and JNK3 (Ki = 1400nM).
Catalog NO: CT-VX11e
Synonym: ERK 11e
CAS NO: 896720-20-​0
Mol. Formula: C24H20Cl2FN5O2∙0.1HCl
MW: 505
** A product with 100% optical purity, coming with a perfect Quantitative Elemental Analysis. Grams in stock, same day shipping.