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Home > Epigenetics Resch Products > HDAC6-Specific Inhibitors > Tubastatin A

Tubastatin A

Tubastatin A is a potent HDAC6 inhibitor with an IC50 value of 15 nM. Comparatively, it demonstrates over 1,000-fold selectivity against all other HDAC isoforms (IC50s >16 μM), excluding HDAC8 (IC50 = 0.9 μM). Tubastatin A induces α-tubulin hyperacetylation at 2.5 μM in primary cortical neuron cultures. In a model of oxidative stress induced by glutathione depletion, tubastatin A displays dose-dependent neuronal protection of primary cortical neuron cultures at 5-10 μM.

Catalog NO:	CT-TUBA
Synonym:
CAS NO:	1310693-92-5
Mol. Formula:	C₂₀H₂₁N₃O₂∙HCl ∙ 0.4H₂O
MW:	379.1

** An off-white to beige powder (see attached picture), 99.5% pure + impeccable 1H-NMR + a high-precision quantitative elemental analysis (ref. 2). Ship within 1 day.

Pricing and OrderingTechnical Data

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NO	Size	Price	In Stock	Quantity
1	10 mg	$105.00	YES
2	50 mg	$250.00	YES
3	100 mg	$420.00	YES
4	200 mg	$750.00	YES

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Solubility : Soluble in Water, DMSO

Storage : Store at 0°C (short term), -20°C (long term), desiccated

Purity : 99.5% (HPLC at 215 nm and 254 nm)

Original QC Data : HPLC- MS, ¹HNMR, and Elemental Analysis Report

Please Pick Batch NO:

Tubastatin A, Lot 01, HCl, Certificate of Analysis.pdf
Tubastatin A, Lot 01, Appearance (Color).pdf
C_K, Tubastatin A, Lot 01, HPLC.pdf
C_K, Tubastatin A, Lot 01, NMR.pdf

1. Butler KV, Kalin J, Brochier C, Vistoli G, Langley B, Kozikowski AP. Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, tubastatin A. J Am Chem Soc. 2010 Aug 11;132(31):10842-6.

2. Our in-house head-to-head assay for ChemieTek's three HDAC6 inhibitors, Tubacin, Tubastatin A and Compound 7, has yielded IC50s of 5, 7 and 4 nM, respectively.

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