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Kinase Inhibitors
Activated Factor VII (Factor VIIa)
Arginase Inhibitor
Adenosine Receptor Ligands
Autotaxin Inhibitor
Bcl-2 Protein Inhibitors/Degraders
BCL-6 Protein Inhibitors
CD73 Immune Pathway Inhibitor/Modulator
Cell Cycle Modulators
Cell Metabolism Modulators
Chemotherapy
CoREST-selective Deacetylase (CoreDAC) inhibitors
Degraders (Protein Degraders)
DNA Methyltransferase Inhibtors
DNA Repair Targeted Therapy
DNA/RNA Synthesis Inhibitor/Blocker
Endoplasmic Reticulum Stress Modulator (ERSM)
Epigenetics Resch Products
Gamma (γ) Secretase (GS) Inhibitors
Glucocorticoid Receptor Antagonist/Modulator
Glutaminase Inhibitor
G-Protein-coupled Receptor Ligands
Heat Shock Protein Research Products
Hedgehog Signaling Pathway Modulators
Hippo Pathway Signaling Inhibitor
HMG-CoA Reductase
Hormone Receptor Modulators
Hydrolase Inhibitors/Modulators
IDO1 (INDOLEAMINE 2,3-DIOXYGENASE 1) Inhibitors
IDH (Isocitrate Dehydrogenase) Inhibitors
IMPDH (Inosine Monosphosphate Dehydrogenase) Inhibitor
Immune Activation Agents/Modulators
Immuno/Inflammatory Mediators
Immunoproteasome Inhibitor
Immuno-oncology Modulators
Immunosuppressants/Immunochemotherapy Agents
Isomerase Inhibitor/Modulator
Kinesin Ligand/Modulator
KRAS Pathway Inhibitors
Liver X receptor (LXR) Agonist/Modulator
Metabolic Pathway Modulators
Monocarboxylate Transporter 1 (MCT 1) Inhibitor/Ligand
Monocarboxylate Transporter 4 (MCT 4) Inhibitor
MTH1 (NUDT1, Human MutT Homologue)
Neuroactive Research Products
Notch/Wnt Signaling Pathway
Nuclear Export Protein Inhibitors/Modulators
Other Enzyme Inhibitors/Modulators
OXPHOS (Mitochondrial Oxidative Phosphorylation of Complex I) Modulator
PD-1/PD-L1 Checkpoint Inhibitors
p53–MDM2 Interaction Inhibitor/Modulator
PCNA (Proliferating Cell Nuclear Antigen)
PDE4 ( Phosphodiesterase Type 4) Inhibitor/Modulators
Phosphatase Inhibitors/Modulators
PLA2 (Phospholipase A2) Inhibitor
Polymerase Inhibitor/Modulator
PPARG Agonist (Peroxisome Proliferator-activated Receptor Gamma Agomist)
Reagents for Biological Assays
RORγ (Retinoic Acid-related Orphan Receptor gamma (γ )) Agonist
SMAC Mimics and Inhibitors of IAP
Stem Cell Research Products
STING (Stimulator of Interferon Genes) Agonist
SUMO Pathway Modulator
TEAD Inhibitor
Toll-like Receptor Agonist
Ubiquitin / Proteasome System
Wnt Signaling Pathway Modulators
YAP/TAZ Signaling Inhibitor
Zinc Finger Protein (IKZF1/3) Degrader
Akt/(PKB (Protein Kinase B)
ALK (Anaplastic Lymphoma Kinase)
AMPK (AMP-Activated Protein Kinase)
ASK1 (Apoptosis Signal-regulating Kinase 1)
ATM (Ataxia Telangiectasia Mutated Kinase)
ATR (Ataxia Telangiectasia and Rad3 Related)
Aurora Kinase
Aurora A Kinase Selective
Aurora B Kinase Selective
Aurora C Kinase Selective
AXL (AXL Receptor Tyrosine Kinase)
Bcr-Abl/c-kit/PDGFR/Src
BTK (Bruton's Tyrosine Kinase)
BUB1 (Budding Uninhibited by Benzimidazoles 1)(Mitotic checkpoint serine/threonine-protein kinase)
CDC7 (Cell Division Cycle 7-related Protein Kinase)
CDK (Cyclin-dependent Kinase)
CDK2 Selective
CDK4 Selective
CDK7 Selective
CDK9 Selective
CDK12/CDK13
CHK (Checkpoint Kinase)
CLK (CDC2-like-Kinase)
CLK2 (CDC2-like Kinase 2)
c-Met
DDK (Dbf4-dependent kinase)
DNA-PK (DNA-Dependent Protein Kinase)
EGFR Mutants
EGFR/HER2
EphB4 (Ephrin Type-B Receptor 4) Kinase
ErbB
Erk (Extracellular signal regulated kinase)
FAK (Focal Adhesion Kinase)
FGFR (Fibroblast Growth Factor Receptor)
FGFR4 Specific
FLT3 (Fms-like Tyrosine Kinase 3)
IGF-1R
JAK (Janus Kinase)
JAK1 Selective
JAK1/JAK2 Selective
JAK2 Selective
JAK3 Selective
LRRK2
MEK/MAPK
Mps1 (Monopolar Spindle 1)
mTOR
NIK (NF-κB-inducing kinase) Inhibitors
P21-Activated Kinases
P70S6K (Ribosomal Protein S6 Kinase)
PDGFR
PDK1
PI3K - p110 Alpha (α) Specific
PI3K - p110 Beta (β) Specific
PI3K - p110 Delta (δ) Specific
PI3K - p110 Gamma (γ) Specific
PI3K - Pan
PI3K/mTOR
PIM
PKC (Protein Kinase C)
PKMYT1
PLK (Polo-like kinase)
PLK1 (Polo-like Kinase 1) Selective
PLK4 (Polo-like Kinase 4) Selective
PTEF-b/CDK9
RAF (Rapidly Accelerated Fibrosarcoma)
RET (Rearranged During Transfection) Kinase
RIP1 (Receptor Interacting Protein 1) Kinase
ROCK (Rho-Associated Protein Kinase)
ROS1 (Proto-oncogene Tyrosine-protein Kinase ROS)
Syk (Spleen Tyrosine Kinase)
TGFβ (Transforming Growth Factor Beta (TGFβ) Receptor) Kinase
TOPK (T–lymphokine-activated killer cell–originated protein kinase)
TRK (Tropomyosin Receptor Kinase) (Tyrosine Receptor Kinase)
TTK (Human Protein Kinase Monopolar Spindle 1 (hMps1))
VEGFR
WEE1
Factor VIIa inhibitor
Bcl-2 Family Protein Inhibitors
BCL-2 Selective Inhibitors
BCL-XL Protein Degrader
BCL-XL Selective Inhibitors
MCL-1 Selective Inhibitors
CD73 (ecto-5'-nucleotidase) Inhibitor
BUB1 (Budding Uninhibited by Benzimidazoles 1)(Mitotic checkpoint serine/threonine-protein kinase)
CBP/β-catenin Modulators
Cell Cycle/DNA Damage
CDK Inhibitors/Modulators
CDC7 (Cell Division Cycle 7-related Protein Kinase)
CHK (Checkpoint Kinase)
CLK (CDC2-like-Kinase)
DNA Replication Modulators/Breakers
Endoplasmic Reticulum Stress Modulator (ERSM)
G-Quadruplex Ligand
IMPDH Inhibitor
Kinesin (CENP-E) Inhibitor
KRAS-G12C Inhibitors
KRASG12C (ON) (Tri-complex) Inhibitor
KRAS-G12D Inhibitors
KRAS-PDEδ Interaction Inhibitor
KRAS-SOS1 Inhibitors
Menin-MLL interaction inhibitors
Mps1 (Monopolar Spindle 1)
Notch Signaling Inhibitors
OXPHOS (Mitochondrial Oxidative Phosphorylation of Complex I) Modulator/Inhibitor
p53-MDM2 Interaction Inhibitor
PCNA (Proliferating Cell Nuclear Antigen)
PRC2 (the catalytic subunit of polycomb repressive complex 2) >
PKMYT1 Kinase Inhibitor
SMAC Mimics and Inhibitors of IAP
Survivin
TTK (Human Protein Kinase Monopolar Spindle 1 (hMps1))
Tubulin
Wee1
Monocarboxylate Transporter 1 (MCT 1) Inhibitor
Mutant Isocitrate Dehydrogenase-1 (IDH1) Inhibitor
Mutant Isocitrate Dehydrogenase-2 (IDH2) Inhibitor
OXPHOS (Mitochondrial Oxidative Phosphorylation of Complex I) Modulator/Inhibitor
Chemotherapy Agents
ATPases (BRG1/BRM)
BET Family Protein Degraders
BET Family Protein Inhibitors
BET/Bromodomain (BDI and BDII) Selective Inhibitors
BET/BRD4 Degrader
BET/BRD9 Degrader
BET Bromodomain II (BDII) Selective Inhibitors
BET/Domain & Sub-set Selective Inhibitors
CBP/P300 Bromodomain Inhibitor
CoreDAC Inhibitors
DNMT1 (DNA Methyltransferase 1) inhibitor
DOT1L Methyltransferase Inhibitor
EP300/CBP HAT (Histone Acetyltransferases) Inhibitor
EZH1/2 Dual Inhibitors
EZH2 Methyltransferase Inhibitors
EZH2 (Mutant) METHYLTRANSFERASE INHIBITOR
HDAC (histone deacetylase) Inhibitors
HDAC1-Specific Inhibitors
HDAC3-Specific Inhibitors
HDAC6-Specific Inhibitors
Lysine specific demethylase 1 (LSD1) Inhibitor
Menin-MLL interaction inhibitors
PRC2 (the catalytic subunit of polycomb repressive complex 2)
PRMT5 (Protein Arginine Methyltransferase 5) Inhibitors/Modulators
PRMTs (Type I) Inhibitors/Modulators
Adenosine Receptor Ligands
Angiotensin II receptor (AT1)
Endothelin receptor antagonist (type A specific)
Heat Shock Proteins HSP90 Inhibitors
Hedgehog Signaling Pathway Inhibitors
HMG-CoA reductase inhibitor
Androgen receptor
Glucocorticoid Receptor
RXRs (retinoid X receptors)
Autotaxin Inhibitor
Caspase-1 Inhibitor
Cathepsin K Inhibitor
Neprilysin (MME) Inhibitor
PDE4 ( phosphodiesterase type 4)
PLA2 Inhibitors
Mutant-IDH1 Inhibitor
Mutant-IDH2 Inhibitor
IMPDH Inhibitor
Liver X receptor (LXR) Agonist/Modulator
RORγ (Retinoic Acid-related Orphan Receptor gamma (γ )) Agonist
STING (STIMULATOR OF INTERFERON GENES) AGONIST
Toll-like Receptor Agonist
Anti-angiogenesis
Anti-fibrosis
Anti-inflammatory
Arginase Inhibitor
Autotaxin Inhibitors
PLA2 Inhibitors
Prostanoid ligand
RIP1 (RECEPTOR INTERACTING PROTEIN 1) KINASE
TGFβ Kinase Inhibitor
Adenosine 2A Receptor Antagonist
Arginase Inhibitor
CD73 (ecto-5'-nucleotidase) Inhibitor
CBP/β-catenin Modulators
CoreDAC Inhibitors
IDO1 (Indoleamine 2,3-dioxygenase 1) Inhibitor
IKZF1/3 (Zinc Finger Protein 1/3)
Immunoproteasome Inhibitor
Liver X receptor (LXR) Agonist/Modulator
mTOR inhibitors
PD-1/PD-L1 CHECKPOINT INHIBITORS
PI3Kγ (GAMMA) Specific Inhibitors
PTPN2/N1 (Protein Tyrosine Phosphatase Non-Receptor Type 2/1) Inhibitors
RORγ (Retinoic Acid-related Orphan Receptor gamma (γ )) Agonist
SHP2 Phosphatase Inhibitor
STING (Stimulator of Interferon Genes) Agonist
SUMOylation Inhibitor
TGFβ Kinase Inhibitor
Toll-like Receptor Agonist
Topoisomerase I
Topoisomerase II
Kinesin (CENP-E) Inhibitor
G12C Mutant Inhibitors
G12D Mutant Inhibitors
KRAS-PDEδ Interaction Inhibitor
Pan-KRAS Inhibitors
SOS1 Inhibitors
Tri-complex KRASG12C (ON) Inhibitor
Tri-complex KRAS inhibitors
Arginase Inhibitor
Glutaminase Inhibitor
IDH (Isocitrate Dehydrogenase) Inhibitors
IMPDH (Inosine Monosphosphate Dehydrogenase) Inhibitor
MAT2A Inhibitor
Monocarboxylate Transporter 1 (MCT 1) Inhibitor
Monocarboxylate Transporter 4 (MCT 4)
OXPHOS (Mitochondrial Oxidative Phosphorylation of Complex I) Modulator
Monocarboxylate Transporter 1 (MCT 1) Inhibitor
MTH1
Neuroactive/BBB Penetrant
Orexin Receptor Antagonists
SDAM (Serotonin-Dopamine Activity Modulator)
TRK (Tropomyosin Receptor Kinase)(Tyrosine Receptor Kinase) Inhibitor
CBP/β-catenin Modulators
Gamma (γ) Secretase (GS) Inhibitors
Notch Signaling Inhibitors
CRM1 (exportin 1) Inhibitor(s)
HCV Protease Inhibitor
HIV-1 integrase Inhibitor
Oxidoreductase Inhibitor
P-p68 (Phosphorylated-p68 RNA Helicase) Inhibitor
Thymidylate synthase inhibitor
p53–MDM2 Interaction Inhibitor
PTPN2/N1 (Protein Tyrosine Phosphatase Non-Receptor Type 2/1) Inhibitors
SHP2 Phosphatase Inhibitor
Wip1 Phosphatase Inhibitor
PARP (Poly (ADP-ribose) polymerase)
Stem cell research
NADD8-Activating Enzyme Inhibtor
Proteasome Inhibitor
SUMOylation Inhibitor
Ubiquitin-Activating Enzyme Inhibitor
USP1 (Ubiquitin Specific Protease 1)
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Kinase Inhibitors
Activated Factor VII (Factor VIIa)
Arginase Inhibitor
Adenosine Receptor Ligands
Autotaxin Inhibitor
Bcl-2 Protein Inhibitors/Degraders
BCL-6 Protein Inhibitors
CD73 Immune Pathway Inhibitor/Modulator
Cell Cycle Modulators
Cell Metabolism Modulators
Chemotherapy
CoREST-selective Deacetylase (CoreDAC) inhibitors
Degraders (Protein Degraders)
DNA Methyltransferase Inhibtors
DNA Repair Targeted Therapy
DNA/RNA Synthesis Inhibitor/Blocker
Endoplasmic Reticulum Stress Modulator (ERSM)
Epigenetics Resch Products
Gamma (γ) Secretase (GS) Inhibitors
Glucocorticoid Receptor Antagonist/Modulator
Glutaminase Inhibitor
G-Protein-coupled Receptor Ligands
Heat Shock Protein Research Products
Hedgehog Signaling Pathway Modulators
Hippo Pathway Signaling Inhibitor
HMG-CoA Reductase
Hormone Receptor Modulators
Hydrolase Inhibitors/Modulators
IDO1 (INDOLEAMINE 2,3-DIOXYGENASE 1) Inhibitors
IDH (Isocitrate Dehydrogenase) Inhibitors
IMPDH (Inosine Monosphosphate Dehydrogenase) Inhibitor
Immune Activation Agents/Modulators
Immuno/Inflammatory Mediators
Immunoproteasome Inhibitor
Immuno-oncology Modulators
Immunosuppressants/Immunochemotherapy Agents
Isomerase Inhibitor/Modulator
Kinesin Ligand/Modulator
KRAS Pathway Inhibitors
Liver X receptor (LXR) Agonist/Modulator
Metabolic Pathway Modulators
Monocarboxylate Transporter 1 (MCT 1) Inhibitor/Ligand
Monocarboxylate Transporter 4 (MCT 4) Inhibitor
MTH1 (NUDT1, Human MutT Homologue)
Neuroactive Research Products
Notch/Wnt Signaling Pathway
Nuclear Export Protein Inhibitors/Modulators
Other Enzyme Inhibitors/Modulators
OXPHOS (Mitochondrial Oxidative Phosphorylation of Complex I) Modulator
PD-1/PD-L1 Checkpoint Inhibitors
p53–MDM2 Interaction Inhibitor/Modulator
PCNA (Proliferating Cell Nuclear Antigen)
PDE4 ( Phosphodiesterase Type 4) Inhibitor/Modulators
Phosphatase Inhibitors/Modulators
PLA2 (Phospholipase A2) Inhibitor
Polymerase Inhibitor/Modulator
PPARG Agonist (Peroxisome Proliferator-activated Receptor Gamma Agomist)
Reagents for Biological Assays
RORγ (Retinoic Acid-related Orphan Receptor gamma (γ )) Agonist
SMAC Mimics and Inhibitors of IAP
Stem Cell Research Products
STING (Stimulator of Interferon Genes) Agonist
SUMO Pathway Modulator
TEAD Inhibitor
Toll-like Receptor Agonist
Ubiquitin / Proteasome System
Wnt Signaling Pathway Modulators
YAP/TAZ Signaling Inhibitor
Zinc Finger Protein (IKZF1/3) Degrader
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New Products (II)
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Kinase Inhibitors
Akt/(PKB (Protein Kinase B)
ALK (Anaplastic Lymphoma Kinase)
AMPK (AMP-Activated Protein Kinase)
ASK1 (Apoptosis Signal-regulating Kinase 1)
ATM (Ataxia Telangiectasia Mutated Kinase)
ATR (Ataxia Telangiectasia and Rad3 Related)
Aurora Kinase
Aurora A Kinase Selective
Aurora B Kinase Selective
Aurora C Kinase Selective
AXL (AXL Receptor Tyrosine Kinase)
Bcr-Abl/c-kit/PDGFR/Src
BTK (Bruton's Tyrosine Kinase)
BUB1 (Budding Uninhibited by Benzimidazoles 1)(Mitotic checkpoint serine/threonine-protein kinase)
CDC7 (Cell Division Cycle 7-related Protein Kinase)
CDK (Cyclin-dependent Kinase)
CDK2 Selective
CDK4 Selective
CDK7 Selective
CDK9 Selective
CDK12/CDK13
CHK (Checkpoint Kinase)
CLK (CDC2-like-Kinase)
CLK2 (CDC2-like Kinase 2)
c-Met
DDK (Dbf4-dependent kinase)
DNA-PK (DNA-Dependent Protein Kinase)
EGFR Mutants
EGFR/HER2
EphB4 (Ephrin Type-B Receptor 4) Kinase
ErbB
Erk (Extracellular signal regulated kinase)
FAK (Focal Adhesion Kinase)
FGFR (Fibroblast Growth Factor Receptor)
FGFR4 Specific
FLT3 (Fms-like Tyrosine Kinase 3)
IGF-1R
JAK (Janus Kinase)
JAK1 Selective
JAK1/JAK2 Selective
JAK2 Selective
JAK3 Selective
LRRK2
MEK/MAPK
Mps1 (Monopolar Spindle 1)
mTOR
NIK (NF-κB-inducing kinase) Inhibitors
P21-Activated Kinases
P70S6K (Ribosomal Protein S6 Kinase)
PDGFR
PDK1
PI3K - p110 Alpha (α) Specific
PI3K - p110 Beta (β) Specific
PI3K - p110 Delta (δ) Specific
PI3K - p110 Gamma (γ) Specific
PI3K - Pan
PI3K/mTOR
PIM
PKC (Protein Kinase C)
PKMYT1
PLK (Polo-like kinase)
PLK1 (Polo-like Kinase 1) Selective
PLK4 (Polo-like Kinase 4) Selective
PTEF-b/CDK9
RAF (Rapidly Accelerated Fibrosarcoma)
RET (Rearranged During Transfection) Kinase
RIP1 (Receptor Interacting Protein 1) Kinase
ROCK (Rho-Associated Protein Kinase)
ROS1 (Proto-oncogene Tyrosine-protein Kinase ROS)
Syk (Spleen Tyrosine Kinase)
TGFβ (Transforming Growth Factor Beta (TGFβ) Receptor) Kinase
TOPK (T–lymphokine-activated killer cell–originated protein kinase)
TRK (Tropomyosin Receptor Kinase) (Tyrosine Receptor Kinase)
TTK (Human Protein Kinase Monopolar Spindle 1 (hMps1))
VEGFR
WEE1
Activated Factor VII (Factor VIIa)
Factor VIIa inhibitor
Arginase Inhibitor
Adenosine Receptor Ligands
Autotaxin Inhibitor
Bcl-2 Protein Inhibitors/Degraders
Bcl-2 Family Protein Inhibitors
BCL-2 Selective Inhibitors
BCL-XL Protein Degrader
BCL-XL Selective Inhibitors
MCL-1 Selective Inhibitors
BCL-6 Protein Inhibitors
CD73 Immune Pathway Inhibitor/Modulator
CD73 (ecto-5'-nucleotidase) Inhibitor
Cell Cycle Modulators
BUB1 (Budding Uninhibited by Benzimidazoles 1)(Mitotic checkpoint serine/threonine-protein kinase)
CBP/β-catenin Modulators
Cell Cycle/DNA Damage
CDK Inhibitors/Modulators
CDC7 (Cell Division Cycle 7-related Protein Kinase)
CHK (Checkpoint Kinase)
CLK (CDC2-like-Kinase)
DNA Replication Modulators/Breakers
Endoplasmic Reticulum Stress Modulator (ERSM)
G-Quadruplex Ligand
IMPDH Inhibitor
Kinesin (CENP-E) Inhibitor
KRAS-G12C Inhibitors
KRASG12C (ON) (Tri-complex) Inhibitor
KRAS-G12D Inhibitors
KRAS-PDEδ Interaction Inhibitor
KRAS-SOS1 Inhibitors
Menin-MLL interaction inhibitors
Mps1 (Monopolar Spindle 1)
Notch Signaling Inhibitors
OXPHOS (Mitochondrial Oxidative Phosphorylation of Complex I) Modulator/Inhibitor
p53-MDM2 Interaction Inhibitor
PCNA (Proliferating Cell Nuclear Antigen)
PRC2 (the catalytic subunit of polycomb repressive complex 2) >
PKMYT1 Kinase Inhibitor
SMAC Mimics and Inhibitors of IAP
Survivin
TTK (Human Protein Kinase Monopolar Spindle 1 (hMps1))
Tubulin
Wee1
Cell Metabolism Modulators
Monocarboxylate Transporter 1 (MCT 1) Inhibitor
Mutant Isocitrate Dehydrogenase-1 (IDH1) Inhibitor
Mutant Isocitrate Dehydrogenase-2 (IDH2) Inhibitor
OXPHOS (Mitochondrial Oxidative Phosphorylation of Complex I) Modulator/Inhibitor
Chemotherapy
Chemotherapy Agents
CoREST-selective Deacetylase (CoreDAC) inhibitors
Degraders (Protein Degraders)
DNA Methyltransferase Inhibtors
DNA Repair Targeted Therapy
DNA/RNA Synthesis Inhibitor/Blocker
Endoplasmic Reticulum Stress Modulator (ERSM)
Epigenetics Resch Products
ATPases (BRG1/BRM)
BET Family Protein Degraders
BET Family Protein Inhibitors
BET/Bromodomain (BDI and BDII) Selective Inhibitors
BET/BRD4 Degrader
BET/BRD9 Degrader
BET Bromodomain II (BDII) Selective Inhibitors
BET/Domain & Sub-set Selective Inhibitors
CBP/P300 Bromodomain Inhibitor
CoreDAC Inhibitors
DNMT1 (DNA Methyltransferase 1) inhibitor
DOT1L Methyltransferase Inhibitor
EP300/CBP HAT (Histone Acetyltransferases) Inhibitor
EZH1/2 Dual Inhibitors
EZH2 Methyltransferase Inhibitors
EZH2 (Mutant) METHYLTRANSFERASE INHIBITOR
HDAC (histone deacetylase) Inhibitors
HDAC1-Specific Inhibitors
HDAC3-Specific Inhibitors
HDAC6-Specific Inhibitors
Lysine specific demethylase 1 (LSD1) Inhibitor
Menin-MLL interaction inhibitors
PRC2 (the catalytic subunit of polycomb repressive complex 2)
PRMT5 (Protein Arginine Methyltransferase 5) Inhibitors/Modulators
PRMTs (Type I) Inhibitors/Modulators
Gamma (γ) Secretase (GS) Inhibitors
Glucocorticoid Receptor Antagonist/Modulator
Glutaminase Inhibitor
G-Protein-coupled Receptor Ligands
Adenosine Receptor Ligands
Angiotensin II receptor (AT1)
Endothelin receptor antagonist (type A specific)
Heat Shock Protein Research Products
Heat Shock Proteins HSP90 Inhibitors
Hedgehog Signaling Pathway Modulators
Hedgehog Signaling Pathway Inhibitors
Hippo Pathway Signaling Inhibitor
HMG-CoA Reductase
HMG-CoA reductase inhibitor
Hormone Receptor Modulators
Androgen receptor
Glucocorticoid Receptor
RXRs (retinoid X receptors)
Hydrolase Inhibitors/Modulators
Autotaxin Inhibitor
Caspase-1 Inhibitor
Cathepsin K Inhibitor
Neprilysin (MME) Inhibitor
PDE4 ( phosphodiesterase type 4)
PLA2 Inhibitors
IDO1 (INDOLEAMINE 2,3-DIOXYGENASE 1) Inhibitors
IDH (Isocitrate Dehydrogenase) Inhibitors
Mutant-IDH1 Inhibitor
Mutant-IDH2 Inhibitor
IMPDH (Inosine Monosphosphate Dehydrogenase) Inhibitor
IMPDH Inhibitor
Immune Activation Agents/Modulators
Liver X receptor (LXR) Agonist/Modulator
RORγ (Retinoic Acid-related Orphan Receptor gamma (γ )) Agonist
STING (STIMULATOR OF INTERFERON GENES) AGONIST
Toll-like Receptor Agonist
Immuno/Inflammatory Mediators
Anti-angiogenesis
Anti-fibrosis
Anti-inflammatory
Arginase Inhibitor
Autotaxin Inhibitors
PLA2 Inhibitors
Prostanoid ligand
RIP1 (RECEPTOR INTERACTING PROTEIN 1) KINASE
TGFβ Kinase Inhibitor
Immunoproteasome Inhibitor
Immuno-oncology Modulators
Adenosine 2A Receptor Antagonist
Arginase Inhibitor
CD73 (ecto-5'-nucleotidase) Inhibitor
CBP/β-catenin Modulators
CoreDAC Inhibitors
IDO1 (Indoleamine 2,3-dioxygenase 1) Inhibitor
IKZF1/3 (Zinc Finger Protein 1/3)
Immunoproteasome Inhibitor
Liver X receptor (LXR) Agonist/Modulator
mTOR inhibitors
PD-1/PD-L1 CHECKPOINT INHIBITORS
PI3Kγ (GAMMA) Specific Inhibitors
PTPN2/N1 (Protein Tyrosine Phosphatase Non-Receptor Type 2/1) Inhibitors
RORγ (Retinoic Acid-related Orphan Receptor gamma (γ )) Agonist
SHP2 Phosphatase Inhibitor
STING (Stimulator of Interferon Genes) Agonist
SUMOylation Inhibitor
TGFβ Kinase Inhibitor
Toll-like Receptor Agonist
Immunosuppressants/Immunochemotherapy Agents
Isomerase Inhibitor/Modulator
Topoisomerase I
Topoisomerase II
Kinesin Ligand/Modulator
Kinesin (CENP-E) Inhibitor
KRAS Pathway Inhibitors
G12C Mutant Inhibitors
G12D Mutant Inhibitors
KRAS-PDEδ Interaction Inhibitor
Pan-KRAS Inhibitors
SOS1 Inhibitors
Tri-complex KRASG12C (ON) Inhibitor
Tri-complex KRAS inhibitors
Liver X receptor (LXR) Agonist/Modulator
Metabolic Pathway Modulators
Arginase Inhibitor
Glutaminase Inhibitor
IDH (Isocitrate Dehydrogenase) Inhibitors
IMPDH (Inosine Monosphosphate Dehydrogenase) Inhibitor
MAT2A Inhibitor
Monocarboxylate Transporter 1 (MCT 1) Inhibitor
Monocarboxylate Transporter 4 (MCT 4)
OXPHOS (Mitochondrial Oxidative Phosphorylation of Complex I) Modulator
Monocarboxylate Transporter 1 (MCT 1) Inhibitor/Ligand
Monocarboxylate Transporter 1 (MCT 1) Inhibitor
Monocarboxylate Transporter 4 (MCT 4) Inhibitor
MTH1 (NUDT1, Human MutT Homologue)
MTH1
Neuroactive Research Products
Neuroactive/BBB Penetrant
Orexin Receptor Antagonists
SDAM (Serotonin-Dopamine Activity Modulator)
TRK (Tropomyosin Receptor Kinase)(Tyrosine Receptor Kinase) Inhibitor
Notch/Wnt Signaling Pathway
CBP/β-catenin Modulators
Gamma (γ) Secretase (GS) Inhibitors
Notch Signaling Inhibitors
Nuclear Export Protein Inhibitors/Modulators
CRM1 (exportin 1) Inhibitor(s)
Other Enzyme Inhibitors/Modulators
HCV Protease Inhibitor
HIV-1 integrase Inhibitor
Oxidoreductase Inhibitor
P-p68 (Phosphorylated-p68 RNA Helicase) Inhibitor
Thymidylate synthase inhibitor
OXPHOS (Mitochondrial Oxidative Phosphorylation of Complex I) Modulator
PD-1/PD-L1 Checkpoint Inhibitors
p53–MDM2 Interaction Inhibitor/Modulator
p53–MDM2 Interaction Inhibitor
PCNA (Proliferating Cell Nuclear Antigen)
PDE4 ( Phosphodiesterase Type 4) Inhibitor/Modulators
Phosphatase Inhibitors/Modulators
PTPN2/N1 (Protein Tyrosine Phosphatase Non-Receptor Type 2/1) Inhibitors
SHP2 Phosphatase Inhibitor
Wip1 Phosphatase Inhibitor
PLA2 (Phospholipase A2) Inhibitor
Polymerase Inhibitor/Modulator
PARP (Poly (ADP-ribose) polymerase)
PPARG Agonist (Peroxisome Proliferator-activated Receptor Gamma Agomist)
Reagents for Biological Assays
RORγ (Retinoic Acid-related Orphan Receptor gamma (γ )) Agonist
SMAC Mimics and Inhibitors of IAP
Stem Cell Research Products
Stem cell research
STING (Stimulator of Interferon Genes) Agonist
SUMO Pathway Modulator
TEAD Inhibitor
Toll-like Receptor Agonist
Ubiquitin / Proteasome System
NADD8-Activating Enzyme Inhibtor
Proteasome Inhibitor
SUMOylation Inhibitor
Ubiquitin-Activating Enzyme Inhibitor
USP1 (Ubiquitin Specific Protease 1)
Wnt Signaling Pathway Modulators
YAP/TAZ Signaling Inhibitor
Zinc Finger Protein (IKZF1/3) Degrader
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StemRegenin 1
StemRegenin 1
StemRegenin 1 (SR1) (CAS No. 1227633-49-9) promotes the ex vivo expansion of CD34+ cells. Culture of HSCs with SR1 led to a 50-fold increase in cells expressing CD34 and a 17-fold increase in cells that retain the ability to engraft immunodeficient mice. Mechanistic studies show that SR1 acts by antagonizing the aryl hydrocarbon receptor (AHR). The identification of SR1 and AHR modulation as a means to induce ex vivo HSC expansion should facilitate the clinical use of HSC therapy.
Catalog NO:
CT-SR1
Synonym:
SR1
CAS NO:
1227633-49-9
Mol. Formula:
C
24
H
23
N
5
OS ∙ 0.7HCl ∙ 0.2H2O
MW:
458.7
** Grams in stock from Indianapolis USA. A white solid/powder, clean (>99% by HPLC), coming with an excellent quantitative elemental analysis. Ship within 1 day.
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10 mg
$70.00
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50 mg
$250.00
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100 mg
$420.00
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Solubility :
Soluble in DMSO
Storage :
Store at 0°C (short term), -20°C (long term), desiccated
Purity :
99% (HPLC)
Original QC Data :
HPLC-MS,
1
HNMR, and Quantitative Elemental Analysis
Please Pick Batch NO:
1
Current Lot, Certificate of Analysis
1: Anthony E. Boitano, Jian Wang et al., Aryl Hydrocarbon Receptor Antagonists Promote the Expansion of Human Hematopoietic Stem Cells, Science, 2010, 329 (5997): 1345-1348.
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