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Home > Kinase Inhibitors > RAF (Rapidly Accelerated Fibrosarcoma) > Sorafenib (free base)

Sorafenib (free base)

An inhibitor of Raf kinase, Platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF) receptor 2 & 3 kinases.

Catalog NO:	CT-SR001
Synonym:	Nexavar
CAS NO:	284461-73-0
Mol. Formula:	C₂₁H₁₆ClF₃N₄O₃
MW:	464.8

** A re-crystallized crystalline solid, >99.5% by HPLC, + A perfect (spot-on) Quantitative Elemental Analysis. Bulk in stock from Indianapolis USA. Ship within 1 day.

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NO	Size	Price	In Stock	Quantity
1	100 mg	$60.00	YES
2	500 mg	$120.00	YES
3	1 g	$180.00	YES

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Solubility : Soluble in DMSO

Storage : Store at 0°C (short term), -20°C (long term), desiccated

Purity : > 99% (HPLC)

Original QC Data : ¹HNMR, HPLC, and Quantitative Elemental Anlysis

Please Pick Batch NO:

Sorafinib (free base), SR-09AR, COA.pdf

1. Davies JM, Dhruva NS, Walko CM, Socinski MA, Bernard S, Hayes DN, Kim WY, Ivanova A, Keller K, Hilbun LR, Chiu M, Dees EC, Stinchcombe TE. A phase I trial of sorafenib combined with cisplatin/etoposide or carboplatin/pemetrexed in refractory solid tumor patients. Lung Cancer. 2010 Jun 24. [Epub ahead of print] PubMed PMID: 20580118.

2. Haubeiss S, Schmid JO, Muerdter TE, Sonnenberg M, Friedel G, van der Kuip H, Aulitzky WE. Dasatinib reverses Cancer-associated Fibroblasts (CAFs) from primary Lung Carcinomas to a Phenotype comparable to that of normal Fibroblasts. Mol Cancer. 2010 Jun 27;9(1):168. [Epub ahead of print] PubMed PMID: 20579391.

3. Siegel AB, Olsen SK, Magun A, Brown RS Jr. Sorafenib: Where do we go from here? Hepatology. 2010 Mar 1;52(1):360-369. [Epub ahead of print] PubMed PMID: 20578152.

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