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Home > Epigenetics Resch Products > HDAC (histone deacetylase) Inhibitors > Romidepsin

Romidepsin

Romidepsin is an inhibitor of HDAC (Histone Deacetylases). It potently inhibits HDAC1 and HDAC2 with IC50 of 1.6 nM and 3.9 nM, respectively, and is relatively weak in inhibiting HDAC4 and HDAC6 with IC50 of 25 nM and 790 nM, respectively. It inhibits the growth of U-937, K562, and CCRF-CEM cells with IC50 of 5.92 nM, 8.36 nM, and 6.95 nM, respectively. Romidepsin induces apoptosis in chronic lymphocytic leukemia (CLL) cells at a concentration corresponding to that at which H3 and H4 acetylation and HDAC inhibition occurs, selectively involving activation of caspase 8 and effector caspase 3, as well as down-regulation of c-FLIP protein.

Catalog NO:	CT-ROMI
Synonym:	FK228, Depsipeptide, FR901228
CAS NO:	128517-07-7
Mol. Formula:	C₂₄H₃₆N₄O₆S₂
MW:	540.7

** White Crystalline Powder (See attached picture). >99% purity. In stock. Prompt.

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NO	Size	Price	In Stock	Quantity
1	1 mg	$100.00	YES
2	5 mg	$295.00	YES

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Solubility : In DMSO

Storage : Store at 0°C (short term), -20°C (long term), deciccated

Purity : >99% (HPLC at 220 nm)

Original QC Data : HPLC-MS and NMR

Please Pick Batch NO:

Romidepsin, Lot 02, Certificate of Analysis.pdf
Romidepsin (FK228), Lot 02, Visual Appearance.pdf
Chemietek, Romidepsin, Lot 02, HPLC-MS.pdf
Chemietek, Romidepsin, Lot 02, NMR.pdf

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