AVN944 (VX-944, AVN-944)  

Formula Image
Catalog Number:
VX-944, AVN-944
CAS Number:
Mol. Formula:

Technical Data:

Solubility: Soluble in DMSO
Storage: Store at 0 °C (short term), -20 °C (long term), desiccated
Purity: >99.5% chem and stereomerical purity (HPLC and Chiral HPLC at 214 and 254 nm)
Original QC
HPLC-MS, 1HNMR, Chiral HPLC and Quantitative Elemental Analysis
Ambient Temp.


NO. Quantity Price In Stock
1 5 mg $120.00 YES
2 10 mg $180.00 YES
3 50 mg $550.00 YES
4 100 mg $950.00 YES
5 200 mg $1,500.00 YES

Grams in stock from Indianapolis USA. A recrystallized white crystalline powder/solid, with >99.5% chem and stereomerical (ee, de) purity + a perfect quantitative elemental analysis. Ship within 1 day.

Brief Description:

AVN-944 (VX-944) is an orally available, uncompetitive small molecule inhibitor of inosine monophosphate dehydrogenase (IMPDH), an enzyme catalyzing the rate limiting step in the biosynthesis of guanine nucleotides. As IMPDH is overexpressed in some cancer cells, particularly in hematological malignancies, thus inhibition of this enzyme will result in depletion of guanine nucleotide pools, cessation of DNA synthesis, cell cycle block at the Gr(1)/S interface and interference with cell division, and induction of apoptosis. The reduction in guanine nucleotide pools will also interfere with the ability of G-coupled proteins to act as intracellular signal transducers.


1. D. Floryk, et al., Antiproliferative effects of AVN944, a novel inosine 5-monophosphate dehydrogenase inhibitor, in prostate cancer cells, International Journal of Cancer (2008), 123(10), 2294-2302. 2. J. Hamilton, et al., A phase I dose-ranging study of the pharmacokinetics, pharmacodynamics, safety, and tolerability of AVN944, an IMPDH inhibitor, in healthy male volunteers, Journal of Clinical Pharmacology (2009), 49(1), 30-38. 3. M. Huang, et al., Depletion of guanine nucleotides leads to the Mdm2-dependent proteasomal degradation of nucleostemin, Cancer Research (2009), 69(7), 3004-3012.
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