PRODUCT

AVN944 (VX-944, AVN-944)  

Formula Image
Catalog Number:
CT-AVN944
Synonym:
VX-944, AVN-944
CAS Number:
297730-17-7
Mol. Formula:
C25H27N5O5
MW:
477.5

Technical Data:

Solubility: Soluble in DMSO
Storage: Store at 0 °C (short term), -20 °C (long term), desiccated
Purity: >99.5% chem and stereomeric purity (HPLC and Chiral HPLC at 214 and 254 nm)
Original QC
Data:
MS, 1HNMR, HPLC and chiral HPLC.
Shipping
Conditions:
Ambient Temp.

Price:

NO. Quantity Price In Stock
1 5 mg $175.00 YES
2 10 mg $250.00 YES
3 50 mg $750.00 YES
4 100 mg $1,200.00 YES
5 200 mg $1,700.00 YES

Please ask for quote for bulk quantities - save $$. Grams in stock from Indianapolis USA. A clean product with >99.5% chem and stereomeric (ee, de) purity.

Brief Description:

AVN-944 (VX-944) is an orally available, uncompetitive small molecule inhibitor of inosine monophosphate dehydrogenase (IMPDH), an enzyme catalyzing the rate limiting step in the biosynthesis of guanine nucleotides. As IMPDH is overexpressed in some cancer cells, particularly in hematological malignancies, thus inhibition of this enzyme will result in depletion of guanine nucleotide pools, cessation of DNA synthesis, cell cycle block at the Gr(1)/S interface and interference with cell division, and induction of apoptosis. The reduction in guanine nucleotide pools will also interfere with the ability of G-coupled proteins to act as intracellular signal transducers.

References:

1. D. Floryk, et al., Antiproliferative effects of AVN944, a novel inosine 5-monophosphate dehydrogenase inhibitor, in prostate cancer cells, International Journal of Cancer (2008), 123(10), 2294-2302. 2. J. Hamilton, et al., A phase I dose-ranging study of the pharmacokinetics, pharmacodynamics, safety, and tolerability of AVN944, an IMPDH inhibitor, in healthy male volunteers, Journal of Clinical Pharmacology (2009), 49(1), 30-38. 3. M. Huang, et al., Depletion of guanine nucleotides leads to the Mdm2-dependent proteasomal degradation of nucleostemin, Cancer Research (2009), 69(7), 3004-3012.
Page Top

Phone:Toll-free 1-877-343-6578 (US and Canada only) 317-598-0828 Fax:317-598-0835
Mailing Address:Northeast Business Center, 7301 E. 90th Street, Suite 117, Indianapolis, IN 46256 USA