PRODUCT

GSK2334470  

Formula Image
Catalog Number:
CT-GSK233
Synonym:
CAS Number:
1227911-45-6
Mol. Formula:
C25H34N8O
MW:
462.59

Technical Data:

Solubility: Soluble in DMSO
Storage: Store at 0°C (short term), -20°C (long term), desiccated
Purity: >99.5% chem and optical purity (HPLC and chiral HPLC at 214 and 254 nm), [α]20D = - 32.6 o (c 1.17, MeOH)
Original QC
Data:
HPLC, Chiral HPLC, MS and 1HNMR
Shipping
Conditions:
Ambient Temp.

Price:

NO. Quantity Price In Stock
1 10 mg $135.00 YES
2 50 mg $270.00 YES
3 100 mg $450.00 YES
4 200 mg $780.00 YES
5 500 mg $1,450.00 YES

Please ask for quote for bulk quantities (1G, 2G, 5G, 10G, ..., ) - save $$. In stock from Indianapolis USA with confirmed Chirality. Ship within 1 day.

Brief Description:

GSK2334470 is a highly specific and potent inhibitor of PDK1 (3-Phosphoinositide dependent protein kinase-1) with IC50 of 10 nM. It does not suppress activity on other 96 kinases, including Aurora, ROCK, p38 MAPK and PI3K. GSK2334470 has been used in cells to ablate T-loop phosphorylation and activate SGK, S6K1 and RSK as well as suppress the activation of Akt.

References:

1. Najafov, et al., Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1. Biochem.J. (2011), 433 (2) 357. 2.
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