GSK126
- Catalog Number:
-
CT-GSK126
- Synonym:
-
- CAS Number:
- 1346574-57-9
- Mol. Formula:
-
C31H38N6O2
- MW:
-
526.67
Technical Data:
| Solubility: |
Soluble in DMSO
|
| Storage: |
Store at 0°C (short term), -20°C (long term), desiccated
|
| Purity: |
99% chem and optical purity (HPLC and Chiral HPLC)
|
Original QC
Data: |
LC/MS, NMR, HPLC and Chiral HPLC
|
Shipping
Conditions: |
Ambient Temp. |
|
|
Price:
| NO. |
Quantity |
Price |
In Stock |
| 1 |
5 mg |
$130.00 |
YES |
| 2 |
10 mg |
$180.00 |
YES |
| 3 |
50 mg |
$550.00 |
YES |
| 4 |
100 mg |
$850.00 |
YES |
| 5 |
200 mg |
$1,300.00 |
YES |
Please ask for quote for other quantities. Grams in stock from Indianapolis USA.
|
Brief Description:
GSK126 is a highly potent and selective small molecule inhibitor of histone methyltransferase EZH2. It potently inhibits both wild-type and mutant EZH2 methyltransferase activity with similar potencies (Kiapp =0.5–3 nM), independent of substrate used, and is competitive with S-adenosylmethionine (SAM) and noncompetitive with peptide substrates.
References:
1. M. T. McCabe, et al, EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating
mutations. Nature. 2012 Dec 6; 492(7427):108-12.