PRODUCT

GSK126  

Formula Image
Catalog Number:
CT-GSK126
Synonym:
CAS Number:
1346574-57-9
Mol. Formula:
C31H38N6O2
MW:
526.67

Technical Data:

Solubility: Soluble in DMSO
Storage: Store at 0°C (short term), -20°C (long term), desiccated
Purity: >99.5% (HPLC at 254 nm), 99.4% (HPLC at 214 nm), 100% optical purity (Chiral HPLC)
Original QC
Data:
LC/MS, NMR, and Chiral HPLC
Shipping
Conditions:
Ambient Temp.

Price:

NO. Quantity Price In Stock
1 10 mg $135.00 YES
2 50 mg $350.00 YES
3 100 mg $580.00 YES
4 200 mg $800.00 YES
5 500 mg Get quote YES

Bulk quantities in stock from Indianapolis USA, with superior chemical and optical purity, no organic solvents visible by NMR*, made for animal studies. Ship within 1 day.

Brief Description:

GSK126 is a highly potent and selective small molecule inhibitor of histone methyltransferase EZH2. It potently inhibits both wild-type and mutant EZH2 methyltransferase activity with similar potencies (Kiapp =0.5–3 nM), independent of substrate used, and is competitive with S-adenosylmethionine (SAM) and noncompetitive with peptide substrates.

References:

1. M. T. McCabe, et al, EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations. Nature. 2012 Dec 6; 492(7427):108-12. *GSK126 offered by some vendor(s) contains 5-8% dichloromethane (methylene chloride) as revealed by NMR. Dichloromethane (methylene chloride) is toxic to cells and animals.
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