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Activated Factor VII (Factor VIIa)

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Arginase Inhibitor

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IDO1 (INDOLEAMINE 2,3-DIOXYGENASE 1) Inhibitors

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TTK (Human Protein Kinase Monopolar Spindle 1 (hMps1))

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Factor VIIa inhibitor

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CD73 (ecto-5'-nucleotidase) Inhibitor

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CDC7 (Cell Division Cycle 7-related Protein Kinase)

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IMPDH Inhibitor

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Notch Signaling Inhibitors

OXPHOS (Mitochondrial Oxidative Phosphorylation of Complex I) Modulator/Inhibitor

p53-MDM2 Interaction Inhibitor

PCNA (Proliferating Cell Nuclear Antigen)

PRC2 (the catalytic subunit of polycomb repressive complex 2) >

PKMYT1 Kinase Inhibitor

SMAC Mimics and Inhibitors of IAP

TTK (Human Protein Kinase Monopolar Spindle 1 (hMps1))

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Monocarboxylate Transporter 1 (MCT 1) Inhibitor

Mutant Isocitrate Dehydrogenase-1 (IDH1) Inhibitor

Mutant Isocitrate Dehydrogenase-2 (IDH2) Inhibitor

OXPHOS (Mitochondrial Oxidative Phosphorylation of Complex I) Modulator/Inhibitor

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BET Family Protein Inhibitors

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CBP/P300 Bromodomain Inhibitor

CoreDAC Inhibitors

DNMT1 (DNA Methyltransferase 1) inhibitor

DOT1L Methyltransferase Inhibitor

EP300/CBP HAT (Histone Acetyltransferases) Inhibitor

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EZH2 Methyltransferase Inhibitors

EZH2 (Mutant) METHYLTRANSFERASE INHIBITOR

HDAC (histone deacetylase) Inhibitors

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HDAC6-Specific Inhibitors

Lysine specific demethylase 1 (LSD1) Inhibitor

Menin-MLL interaction inhibitors

PRC2 (the catalytic subunit of polycomb repressive complex 2)

PRMT5 (Protein Arginine Methyltransferase 5) Inhibitors/Modulators

PRMTs (Type I) Inhibitors/Modulators

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Adenosine Receptor Ligands

Angiotensin II receptor (AT1)

Endothelin receptor antagonist (type A specific)

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Hedgehog Signaling Pathway Inhibitors

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HMG-CoA reductase inhibitor

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Androgen receptor

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RXRs (retinoid X receptors)

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Autotaxin Inhibitor

Caspase-1 Inhibitor

Cathepsin K Inhibitor

Neprilysin (MME) Inhibitor

PDE4 ( phosphodiesterase type 4)

PLA2 Inhibitors

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Mutant-IDH1 Inhibitor

Mutant-IDH2 Inhibitor

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IMPDH Inhibitor

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Liver X receptor (LXR) Agonist/Modulator

RORγ (Retinoic Acid-related Orphan Receptor gamma (γ )) Agonist

STING (STIMULATOR OF INTERFERON GENES) AGONIST

Toll-like Receptor Agonist

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Anti-angiogenesis

Anti-inflammatory

Arginase Inhibitor

Autotaxin Inhibitors

PLA2 Inhibitors

Prostanoid ligand

RIP1 (RECEPTOR INTERACTING PROTEIN 1) KINASE

TGFβ Kinase Inhibitor

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Adenosine 2A Receptor Antagonist

Arginase Inhibitor

CD73 (ecto-5'-nucleotidase) Inhibitor

CBP/β-catenin Modulators

CoreDAC Inhibitors

IDO1 (Indoleamine 2,3-dioxygenase 1) Inhibitor

IKZF1/3 (Zinc Finger Protein 1/3)

Immunoproteasome Inhibitor

Liver X receptor (LXR) Agonist/Modulator

mTOR inhibitors

PD-1/PD-L1 CHECKPOINT INHIBITORS

PI3Kγ (GAMMA) Specific Inhibitors

PTPN2/N1 (Protein Tyrosine Phosphatase Non-Receptor Type 2/1) Inhibitors

RORγ (Retinoic Acid-related Orphan Receptor gamma (γ )) Agonist

SHP2 Phosphatase Inhibitor

STING (Stimulator of Interferon Genes) Agonist

SUMOylation Inhibitor

TGFβ Kinase Inhibitor

Toll-like Receptor Agonist

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Topoisomerase I

Topoisomerase II

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Kinesin (CENP-E) Inhibitor

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G12C Mutant Inhibitors

G12D Mutant Inhibitors

KRAS-PDEδ Interaction Inhibitor

Pan-KRAS Inhibitors

SOS1 Inhibitors

Tri-complex KRASG12C (ON) Inhibitor

Tri-complex KRAS inhibitors

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Arginase Inhibitor

Glutaminase Inhibitor

IDH (Isocitrate Dehydrogenase) Inhibitors

IMPDH (Inosine Monosphosphate Dehydrogenase) Inhibitor

MAT2A Inhibitor

Monocarboxylate Transporter 1 (MCT 1) Inhibitor

Monocarboxylate Transporter 4 (MCT 4)

OXPHOS (Mitochondrial Oxidative Phosphorylation of Complex I) Modulator

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Monocarboxylate Transporter 1 (MCT 1) Inhibitor

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Neuroactive/BBB Penetrant

Orexin Receptor Antagonists

SDAM (Serotonin-Dopamine Activity Modulator)

TRK (Tropomyosin Receptor Kinase)(Tyrosine Receptor Kinase) Inhibitor

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CBP/β-catenin Modulators

Gamma (γ) Secretase (GS) Inhibitors

Notch Signaling Inhibitors

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CRM1 (exportin 1) Inhibitor(s)

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HCV Protease Inhibitor

HIV-1 integrase Inhibitor

Oxidoreductase Inhibitor

P-p68 (Phosphorylated-p68 RNA Helicase) Inhibitor

Thymidylate synthase inhibitor

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p53–MDM2 Interaction Inhibitor

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PTPN2/N1 (Protein Tyrosine Phosphatase Non-Receptor Type 2/1) Inhibitors

SHP2 Phosphatase Inhibitor

Wip1 Phosphatase Inhibitor

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PARP (Poly (ADP-ribose) polymerase)

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Stem cell research

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NADD8-Activating Enzyme Inhibtor

Proteasome Inhibitor

SUMOylation Inhibitor

Ubiquitin-Activating Enzyme Inhibitor

USP1 (Ubiquitin Specific Protease 1)

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Home > Epigenetics Resch Products > PRMT5 (Protein Arginine Methyltransferase 5) Inhibitors/Modulators > PF-06855800 (PF06855800)

PF-06855800 (PF06855800)

PF-06855800 (PF06855800) is a clinical-stage, SAM-pocket-binding (SAM competitive) PRMT5 inhibitor with high selectivity and affinity (PRMT5-MEP-50, Ki < 0.1 nM) and demonstrates robust and efficacious antiproliferative activity in both in vitro and in vivo models.

Catalog NO:	CT-PF0685
Synonym:	PF06855800
CAS NO:	1989620-04-3
Mol. Formula:	C17H16ClFN4O4∙H2O
MW:	412.8 (or refer to the Certificate of Analysis, batch-specific)

** in vivo Quality material, >99% pure by Achiral and Chiral HPLCs (attached). Monohydrate, validated by a spot-on a Quantitative Elemental Analysis. Bulk stock. Same day shipping.

Pricing and OrderingTechnical Data

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References

NO	Size	Price	In Stock	Quantity
1	5 mg	$120.00	YES
2	10 mg	$190.00	YES
3	50 mg	$680.00	YES

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Solubility : Refer to Certificate of Analysis

Storage : Refer to Certificate of Analysis

Purity : >99% chemically and stereomerically pure (by achiral and chiral HPLCs)

Original QC Data : Achiral and Chiral HPLCs, MS, NMR, and Elemental Analysis Report

Please Pick Batch NO:

PF-06855800, Lot 01, Certificate of Analysis.pdf
PF-06855800, Lot 01, Visual Appearance.pdf

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