BMN-673 (Talazoparib) (MDV-3800) (LT 00673) - Chemietek

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Home > Polymerase Inhibitor/Modulator > PARP (Poly (ADP-ribose) polymerase) > BMN-673 (Talazoparib) (MDV-3800) (LT 00673)

BMN-673 (Talazoparib) (MDV-3800) (LT 00673)

BMN-673 (Talazoparib) (MDV-3800) is an orally bioavailable inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP), potently inhibiting PARP1 and PARP2 enzyme activity with Ki = 1.2 and 0.87 nM, respectively. It inhibits PARP-mediated PARylation in a whole-cell assay with an EC50 of 2.51 nM and prevents proliferation of cancer cells carrying mutant BRCA1/2, with EC50= 0.3 nM (MX-1) and 5 nM (Capan-1), respectively. Displays favorable pharmacokinetic (PK) properties and remarkable antitumor efficacy in the BRCA1 mutant MX-1 breast cancer xenograft model following oral administration as a single-agent or in combination with chemotherapy agents such as temozolomide and cisplatin (ref. 1). It is currently in clinical evaluation.

Catalog NO:	CT-BMN673
Synonym:	Talazoparib, MDV-3800, LT 00673
CAS NO:	1207456-01-6
Mol. Formula:	C19H14F2N6O
MW:	380.4

** in vivo grade material. A single isomer (100% ee by Chiral HPLC). White Crystalline Powder (see attached picture). Bulk Stock (get discounted quote for larger size). Same day shipping.

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NO	Size	Price	In Stock	Quantity
1	5 mg	$100.00	YES
2	10 mg	$150.00	YES
3	50 mg	$375.00	YES
4	100 mg	$625.00	YES

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Solubility : Refer to Certificate of Analysis

Storage : Refer to Certificate of Analysis

Purity : 100% Optically Pure (Chiral HPLC), 99.3%-99.5% chemically Pure by Achiral HPLC at 214 and 254 nm.

Original QC Data : Achiral and Chiral HPLCs, NMR and Quantitative Elemental Analysis Report

Please Pick Batch NO:

BMN-673, Lot 01, Visual Appearance.pdf
BMN-673 (Talazoparib), Lot 01, Certificate of Analysis.pdf

B. Wang, et al, J. Med. Chem., 2016, 59 (1), pp 335–357

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