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OTX-015 (Birabresib)
OTX-015 (Birabresib) is an orally bioavailable synthetic small molecule BET Bromodomain inhibitor, selectively binding to the BRD2/3/4 in a competitive manner, with EC50 values of 10-19 nM. In vitro and in vivo experiments showed that OTX015 targeted NFKB/TLR/JAK/STAT signaling pathways, MYC- and E2F1-regulated genes, cell-cycle regulation, and chromatin structure. Displaying in vitro synergism with several anticancer agents, especially with mTOR and BTK inhibitors (ref 1).
Catalog NO: CT-OTX015
Synonym: Birabresib, Y-803
CAS NO: 202590-98-5
Mol. Formula: C25H22ClN5O2S ∙ 0.7H2O
MW: 504.6
** in vivo Quality Material. >99% purity by Achiral and Chiral HPLCs. Hydrate, validated by a spot-on Elemental Analysis. Bulk stock. Ship within 1 day