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Home > Kinase Inhibitors > VEGFR > Motesanib diphosphate

Motesanib diphosphate

An orally bioavailable inhibitor of a multiple-receptor tyrosine kinase inhibitor with potential antineoplastic activity. Motesanib selectively targets VEGF, PDGF, kit, and Ret receptors, thereby inhibiting angiogenesis and cellular proliferation.

Catalog NO:	CT-MT002
Synonym:	AMG-706
CAS NO:	857876-30-3
Mol. Formula:	C₂₂H₂₃N₅O ∙ 2(H₃PO₄)
MW:	569.44

** Please ask for quote for other quantities. Grams in stock.

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NO	Size	Price	In Stock	Quantity
1	10 mg	$65.00	YES
2	50 mg	$210.00	YES
3	100 mg	$370.00	YES
4	200 mg	$680.00	YES
5	500 mg	$1,585.00	YES

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Solubility : Soluble in water

Storage : Store at 0°C (short term), -20°C (long term), desiccated

Purity : > 99% (HPLC)

Original QC Data : LC/MS, ¹HNMR

There is no COA file for this product

1. Polverino, A., et al., AMG 706, an oral, multikinase inhibitor that selectively targets vascular endothelial growth factor, platelet-derived growth factor, and kit receptors, potently inhibits angiogenesis and induces regression in tumor xenografts, Cancer Research, 2006, 66 (17), 8715-8721.

2. Sherman, S.I, et al, Motesanib Diphosphate in Progressive Differentiated Thyroid Cancer, N Engl J Med. 2008, 359:31-42.

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