MK-1775 (Adavosertib) (AZD1775) - Chemietek

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Home > Kinase Inhibitors > WEE1 > MK-1775 (Adavosertib) (AZD1775)

MK-1775 (Adavosertib) (AZD1775)

MK-1775 (Adavosertib) (AZD1775) is an orally bioavailable, clinical stage, small molecule inhibitor of Wee1, a kinase that phosphorylates CDC2 to inactivate the CDC2/cyclin B complex (regulating the G2 checkpoint). Since most human cancers harbor p53-dependent G1 checkpoint abnormalities, they are dependent on the G2 checkpoint. G2 checkpoint abrogation may therefore sensitize p53 deficient tumor cells to anti-cancer agents.

Catalog NO:	CT-MK1775
Synonym:	Adavosertib, AZD1775
CAS NO:	955365-80-7
Mol. Formula:	C₂₇H₃₂N₈O₂
MW:	500.6 (refer to Certificate of Analysis, batch-specific)

** in vivo grade material. >99.5% by HPLC (attached), a recrystallized yellow powder, clean and impeccable. Monohydrate, validated by a spot-on Quantitative Microanalysis. Bulk Stock!! Same day shipping.

Pricing and OrderingTechnical Data

QC & Certificates

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NO	Size	Price	In Stock	Quantity
1	10 mg	$80.00	YES
2	50 mg	$200.00	YES
3	100 mg	$340.00	YES
4	200 mg	$580.00	YES

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Solubility : In DMSO

Storage : Store at 0 °C (short term), -20 °C (long term), desiccated

Purity : >99.5% (HPLC)

Original QC Data : HPLC-MS, ¹HNMR, and Quantitative Elemental Analysis

Please Pick Batch NO:

MK-1775 (Adavosertib), Lot 04, Certificate of Analysis.pdf
C_K, MK-1775, Lot 04, HPLC.pdf
C_K, MK-1775, Lot 04, NMR.pdf

1: Leijen S, el at., Curr Clin Pharmacol. 2010 Apr 21. [Epub ahead of print] PubMed PMID: 20406171.

2: Hirai H, et al., Cancer Biol Ther. 2010 Apr 4;9 (7). [Epub ahead of print] PubMed PMID: 20107315.

3: Hirai H, et al., Mol Cancer Ther. 2009 Nov; 8(11):2992-3000.

4: Mizuarai S, et al., Mol Cancer. 2009 Jun 8; 8:34. PubMed PMID: 19500427; PubMed Central PMCID: PMC2700070.

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