LGX818 (Encorafenib) - Chemietek

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Home > Kinase Inhibitors > RAF (Rapidly Accelerated Fibrosarcoma) > LGX818 (Encorafenib)

LGX818 (Encorafenib)

Encorafenib (LGX818) is a selective ATP-competitive RAF kinase inhibitor of B-RafV600E mutant melanoma cell proliferation (EC50 = 4 nM) with little activity against wild-type B-Raf or a panel of 100 other kinases (IC50s = 900 nM). At oral doses of 6 mg/kg in human melanoma xenograft models, Encorafenib was shown to decrease phosphorylation of the B-Raf substrate MEK.

Catalog NO:	CT-LGX818
Synonym:	Encorafenib, NVP-LGX818
CAS NO:	1269440-17-6
Mol. Formula:	C₂₂H₂₇ClFN₇O₄S
MW:	540.0

** in vivo Quality Material. >99.5% Pure by Achiral and Chiral HPLCs (attached). Anhydrous, validated by a spot-on quantitative elemental analysis. Bulk (Get quote for 1, 2, 5G). Same day shipping.

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NO	Size	Price	In Stock	Quantity
1	10 mg	$90.00	YES
2	50 mg	$260.00	YES
3	100 mg	$430.00	YES
4	200 mg	$730.00	YES

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Solubility : Refer to Certificate of Analysis

Storage : Refer to Certificate of Analysis

Purity : >99.5% Pure by Achiral and Chiral HPLCs

Original QC Data : Achiral and Chiral HPLCs, MS, NMR, and Quantitative Elemental analysis Report

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LGX818 (Encorafenib), Lot 02, Certificate of Analysis.pdf
LGX818 (Encorafenib), Lot 02, Visual Appearance.pdf

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