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IPI-145
IPI-145 is an orally bioavailable PI3K/P110δ/γ isoform-specific inhibitor, with Ki values: P110δ (23 pM), P110γ (243 pM), p110α (25900 pM) and p110β (1564 pM). IPI-145 exerts profound effects on adaptive and innate immunity by inhibiting B and T cell proliferation, blocking neutrophil migration, and inhibiting basophil activation. IPI-145 showed potent activity in collagen-induced arthritis, ovalbumin-induced asthma, and systemic lupus erythematosus rodent models (ref 1).
Catalog NO: CT-IPI145
Synonym: Duvelisib, INK-1197
CAS NO: 1201438-56-3
Mol. Formula: C22H17ClN6O ∙ 0.5H2O
MW: 425.9
** in vivo Quality Material, >99% by achiral and chiral HPLCs (attached). Hydrate, validated by a spot-on Quantitative Elemental Analysis. Bulk!! Prompt.