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Home > Kinase Inhibitors > Akt/(PKB (Protein Kinase B) > GSK690693

GSK690693

A novel ATP competitive, pan-AKT kinase inhibitor with IC50 values of 2, 13, and 9 nM against AKT1, 2, and 3, respectively. It inhibits GSK3β phosphorylation and tumor growth in human breast carcinoma (BT474) xenografts, and induces growth inhibition and apoptosis in acute lymphoblastic leukemia cell lines.

Catalog NO:	CT-GSK690
Synonym:
CAS NO:	937174-76-0
Mol. Formula:	C₂₁H₂₇N₇O₃ ∙ 0.6HCl
MW:	447.4

** A recrystallized, pale yellow crystalline solid (picture attached), clean (>99.5% by HPLC) and optically pure (100% ee by Chiral HPLC) product, coming with an excellent quantitative elemental analysis. Bulk Stock!! Ship within 1 day.

Pricing and OrderingTechnical Data

QC & Certificates

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NO	Size	Price	In Stock	Quantity
1	5 mg	$100.00	YES
2	10 mg	$140.00	YES
3	50 mg	$300.00	YES
4	100 mg	$500.00	YES
5	200 mg	$800.00	YES

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Solubility : In DMSO, Water with 1 eq of acid

Storage : Store at 0°C (short term), -20°C (long term), desiccated

Purity : >99.5% chem and optical purity (HPLC and chiral HPLC at 220 nm)

Original QC Data : HPLC-MS, ¹HNMR, Chiral HPLC, and Quantitative Elemental Analysis

Please Pick Batch NO:

GSK690693, Lot 02, Certificate of Analysis.pdf
GSK690693, Lot 02, Visual Appearance.pdf

1. M.C. Crouthamel, J.A. Kahana, S. Korenchuk, S.Y. Zhang, G. Sundaresan, D.J. Eberwein, K.K. Brown, R. Kumar. Mechanism and management of AKT inhibitor-induced hyperglycemia. Clin. Cancer Res. 2009, 15(1), 217-225.

2. Dirk A. Heerding, Nelson Rhodes, Jack D. Leber, et al., Identification of 4-(2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a Novel Inhibitor of AKT Kinase, J. Med. Chem., 2008, 51 (18), 5663-5679.

3. D.S. Levy, J.A. Kahana, R. Kumar. AKT inhibitor, GSK690693, induces growth inhibition and apoptosis in acute lymphoblastic leukemia cell lines, Blood. 2009, 113(8), 1723-1729.

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