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Home > Kinase Inhibitors > PLK (Polo-like kinase) > GSK461364

GSK461364

A highly potent, selective and ATP-competitive inhibitor of polo-like kinase 1 (K_i = 2.2 nM), and is 400-fold greater potency than PLK 2 and 3, currently in clinical trial.

Catalog NO:	CT-GSK461
Synonym:
CAS NO:	929095-18-1
Mol. Formula:	C₂₇H₂₈F₃N₅O₂S ∙ 0.3HCl
MW:	554.5

** in vivo Quality material, >99% pure by Achiral and Chiral HPLCs. A white to off-white recrystallized powder. Bulk stock, prompt.

Pricing and OrderingTechnical Data

QC & Certificates

References

NO	Size	Price	In Stock	Quantity
1	10 mg	$145.00	YES
2	50 mg	$400.00	YES
3	100 mg	$650.00	YES

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Solubility : Soluble in DMSO, and water with 2.0 eq. of HCl.

Storage : 0 °C (short term), -20 °C (long term), Desiccated

Purity : >99% by HPLC, 100% optical purity (Chiral HPLC)

Original QC Data : HPLC-MS, ¹HNMR, Chiral HPLC, and Quantitative Elemental Analysis

Please Pick Batch NO:

GSK461364, Lot 01, Certificate of Analysis.pdf
GSK461364, Lot 01, Visual Appearance.pdf

1. T.R. Rheault, et al., Heteroaryl-linked 5-(1H-benzimidazol-1-yl)-2-thiophenecarboxamides: potent inhibitors of polo-like kinase 1 (PLK1) with improved drug-like properties. Bioorg. Med. Chem. Lett. 2010, 20(15), 4587-92

2. K.A. Emmitte, et al., Design of potent thiophene inhibitors of polo-like kinase 1 with improved solubility and reduced protein binding. Bioorg. Med. Chem. Lett., 2009, 19(6), 1694-7.

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