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GSK3326595 (EPZ015938)
GSK3326595 (EPZ015938) is an orally active, potent, selective, SAM uncompetitive, peptide competitive, slow binding inhibitor of protein arginine methyltransferase 5 (PRMT5)/MEP50 with a biochemical IC50 of 6 nM (ref 1), and is >4,000-fold selective for PRMT5/MEP50 over any other enzyme when tested in a panel containing 20 other histone methyltransferases (ref 1). Display potent antitumor activities in vitro and in vivo in animal models. It is currently in clinical evaluation for the treatment of solid tumors and non-Hodgkin's lymphoma.
Catalog NO: CT-GSK332
Synonym: EPZ015938
CAS NO: 1616392-22-3
Mol. Formula: C24H32N6O3
MW: 452.6 (or refer to Certificate of Analysis, batch-specific)
** 99.9% Pure, in vivo grade material. A pale yellow crystalline solid (picture attached). Clean and Impeccable (see attached Original QC Docs). Bulk Stock!! Same Day Shipping.