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Home > Kinase Inhibitors > PDK1 > GSK2334470

GSK2334470

GSK2334470 is a highly specific and potent inhibitor of PDK1 (3-Phosphoinositide dependent protein kinase-1) with IC50 of 10 nM. It does not suppress activity on other 96 kinases, including Aurora, ROCK, p38 MAPK and PI3K. GSK2334470 has been used in cells to ablate T-loop phosphorylation and activate SGK, S6K1 and RSK as well as suppress the activation of Akt.

Catalog NO:	CT-GSK233
Synonym:
CAS NO:	1227911-45-6
Mol. Formula:	C₂₅H₃₄N₈O ∙ 0.3H₂O
MW:	468

** in vivo Quality material. >99.5% by Achiral and Chiral HPLCs. A stereomerically pure single isomer (Clinically active isomer) with 100%ee, de (All QC Docs attached), coming with a quantitative microanalysis. Bulk stock!! Prompt

Pricing and OrderingTechnical Data

QC & Certificates

References

NO	Size	Price	In Stock	Quantity
1	10 mg	$135.00	YES
2	50 mg	$270.00	YES
3	100 mg	$450.00	YES
4	200 mg	$780.00	YES

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Solubility : Soluble in DMSO

Storage : Store at 0°C (short term), -20°C (long term), desiccated

Purity : >99.5% by Achiral and Chiral HPLCs

Original QC Data : Achiral and Chiral HPLCsMS, ¹HNMR, and Quantitative Elemental Analysis Report.

Please Pick Batch NO:

GSK2334470, Current Lot, Certificate of Analysis
GSK233470, Lot 01 (current lot), Visual Appearance.pdf

1. Najafov, et al., Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1. Biochem.J. (2011), 433 (2) 357.

2.

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