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Home > Neuroactive Research Products > Neuroactive/BBB Penetrant > GNE-7915

GNE-7915

GNE-7915 is a Blood-Brain Barrier (BBB) penetrablesmall molecule inhibitor of Leucine-Rich Repeat Kinase 2 (LRRK2). It potently (Ki = 1 nM/ IC50 =9 nM (cell Assay)) and selectively (1 out of 187) inhibits the enzyme activity, and is CNS active, metabolically stable (refs 1-2).

Catalog NO:	CT-GNE79
Synonym:
CAS NO:	1351761-44-8
Mol. Formula:	C₁₉H₂₁F₄N₅O₃
MW:	443.4

** in vivo grade material. >99.5% pure, white crystalline powder (pic attached), with a spot-on quantitative elemental analysis. Bulk stock. Ship within 1 day.

Pricing and OrderingTechnical Data

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NO	Size	Price	In Stock	Quantity
1	10 mg	$135.00	YES
2	50 mg	$250.00	YES
3	100 mg	$395.00	YES
4	200 mg	$650.00	YES

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Solubility : Soluble in DMSO

Storage : Store at 0°C (short term), -20°C (long term), desiccated

Purity : >99.5% (HPLC at 214 and 254 nm)

Original QC Data : HPLC-MS, ¹HNMR and Quantitative Elemental Analysis

Please Pick Batch NO:

GNE-7915, Current, HPLC-MS
CHEMIETEK, GNE-7915, Lot 01, NMR.pdf
GNE-7915, lot 01, Apearance (color).pdf
GNE-7915, Lot 01, Certificate of Analysis.pdf

1. A.A. Estrada, et al., Discovery of Highly Potent, Selective, and Brain-Penetrable Leucine-Rich Repeat Kinase 2 (LRRK2) Small Molecule Inhibitors, J. Med. Chem., 2012, 55 (22), pp 9416–9433

2. M.E. Kavanagh, et al, Bio.& Med. Chem Letters, 2013, 23 (13) Pages 3690–3696

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