Welcome visitor Log In - or - Register
(
0 items /
$0.00
)
View Cart
Check Out
four ways
Quick Search:
Skip Navigation LinksHome > Kinase Inhibitors > MEK/MAPK > GDC-0973 (Cobimetinib)
GDC-0973 (Cobimetinib)
GDC-0973 (Cobimetinib, XL518) is an orally bioavailable, potent and selective small-molecule inhibitor of mitogen-activated protein kinase 1 (MAP2K1 or MEK1). It blocks the catalytic activity of MEK1, resulting in inhibition of extracellular signal-related kinase 2 (ERK2) phosphorylation and activation, and decreased tumor cell proliferation. It is currently being used, in combination with Vemurafenib (PLX4032, our Prod No CT-P4032), in the treatment of unresectable or metastatic melanoma with a BRAF V600E or V600K mutation.
Catalog NO: CT-G0973
Synonym: GDC0973, Cobimetinib, RG7420, XL518, XL-518
CAS NO: 934660-93-2
Mol. Formula: C21H21F3IN3O2
MW: 531.3
** in vivo Quality Material. >99% by Achiral and Chiral HPLCs (Attached). Anhydrous, validated by a spot-on Elemental Analysis. Bulk stock. Same day shipping.