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Home > Isomerase Inhibitor/Modulator > Topoisomerase II > Etoposide phosphate

Etoposide phosphate

Etoposide phosphate is a phosphate salt of a semisynthetic derivative of podophyllotoxin. Etoposide binds to the enzyme topoisomerase II, inducing double-strand DNA breaks, inhibiting DNA repair, and resulting in decreased DNA synthesis and tumor cell proliferation. Cells in the S and G2 phases of the cell cycle are most sensitive to this agent.

Catalog NO:	CT-EPH
Synonym:	VP-16
CAS NO:	117091-64-2
Mol. Formula:	C₂₉H₃₃O₁₆P
MW:	668.54

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NO	Size	Price	In Stock	Quantity
1	25 mg	$85.00	YES
2	100 mg	$250.00	YES
3	500 mg	$900.00	YES

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Solubility : Soluble in DMSO and water

Storage : Store at 0°C (short term), -20°C (long term), desiccated

Purity : 99% (HPLC)

Original QC Data : LC/MS, ¹HNMR

There is no COA file for this product

1. Guillaume DJ, Doolittle ND, Gahramanov S, Hedrick NA, Delashaw JB, Neuwelt EA. Intra-arterial chemotherapy with osmotic blood-brain barrier disruption for aggressive oligodendroglial tumors: results of a phase I study. Neurosurgery. 2010 Jan;66(1):48-58; discussion 58.

2. Lata H, Mizuno CS, Moraes RM. The role of biotechnology in the production of the anticancer compound podophyllotoxin. Methods Mol Biol. 2009;547:387-402.

3. Xu H, Lv M, Tian X. A review on hemisynthesis, biosynthesis, biological activities, mode of action, and structure-activity relationship of podophyllotoxins: 2003-2007. Curr Med Chem. 2009;16(3):327-49. Review.

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