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Home > Epigenetics Resch Products > EZH2 Methyltransferase Inhibitors > EPZ005687

EPZ005687

EPZ005687 is a potent and selective small molecule inhibitor of histone methyltransferase EZH2 ( Ki = 24 nM). It has greater than 500-fold selectivity against 15 other protein methyltransferases and has 50-fold selectivity against the closely related enzyme EZH1.

Catalog NO:	CT-EPZ687
Synonym:
CAS NO:	1396772-26-1
Mol. Formula:	C₃₂H₃₇N₅O₃ ∙ 0.8HCl
MW:	568.8

** >99.5% by HPLC (at 214 and 254 nm). A recrystallized powder (pic attached). Bulk Stock (get discounted quote for larger sizes)! Same day shipping.

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NO	Size	Price	In Stock	Quantity
1	10 mg	$100.00	YES
2	50 mg	$280.00	YES
3	100 mg	$450.00	YES

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Solubility : DMSO

Storage : Store at 0°C (short term), -20°C (long term), desiccated

Purity : >99.5% (HPLC at 214 and 254 nm)

Original QC Data : HPLC-MS, ¹HNMR, and Quantitative Elemental Analysis.

Please Pick Batch NO:

EPZ005687, Lot 02, Certificate of Analysis.pdf
EPZ005687, Lot 02, Appearance (color).pdf

1. SK Knutson, et al., A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells, Nat Chem Biol. 2012 Nov;8(11):890-6

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