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Home > Kinase Inhibitors > JAK3 Selective > Decernotinib (VX-509)

Decernotinib (VX-509)

Decernotinib (VX-509; VRT-831509, Adelatinib) is an orally bioavailable Janus kinase 3 (JAK3) inhibitor, potently and selectively inhibiting the enzyme with an in vitro Ki of 2.5 nM, and IC50 of 50-170 nM in cellular assays dependent on JAK3 activity. Highly selective, displaying no activity (with limited or no measureable potency) towards other JAK and non-JAK enzymes. Showed in vivo activity in two animal models of aberrant immune function, and demonstrated dose-dependent reduction in ankle swelling and paw weight and improved paw histopathology scores in the rat collagen-induced arthritis model (ref.1).

Catalog NO:	CT-DECE
Synonym:	VX-509, VRT-831509, Adelatinib
CAS NO:	944842-54-0
Mol. Formula:	C₁₈H₁₉F₃N₆O
MW:	392.4

** A snow-white crystalline powder, recrystallized (picture attached), clean (>99.5% by achiral HPLC), optically pure (100%ee by chiral HPLC), coming with a perfect quantitative elemental analysis. Bulk Stock!! Ship within 1 day.

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NO	Size	Price	In Stock	Quantity
1	5 mg	$110.00	YES
2	10 mg	$160.00	YES
3	50 mg	$380.00	YES
4	100 mg	$620.00	YES
5	200 mg	$1,020.00	YES

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Solubility : Soluble in DMSO

Storage : Store at 0-4°C (short term), -20°C (long term), desiccated

Purity : 100% optical purity (Chiral HPLC), >99.5% purity (HPLC at 214 and 254 nm),

Original QC Data : HPLC-MS, ¹HNMR, Chiral HPLC, and Quantitative Elemental Analysis

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Current, Certificate of Analysis
Current Lot, NMR
Current Lot, HPLC-MS and Chiral HPLC
Decernotinib, Lot 01, Visual Appearance (color).pdf

1. S. Mahajan, et al, VX-509 is a potent and selective Janus kinase 3 (JAK3) inhibitor that attenuates inflammation in animal models of autoimmune disease. J .Pharmacol Exp Ther. 2015 May;353(2):405-14. doi: 10.1124/jpet.114.221176. Epub 2015 Mar 1

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