DCC-2036 (Rebastinib) - Chemietek

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Home > Kinase Inhibitors > Bcr-Abl/c-kit/PDGFR/Src > DCC-2036 (Rebastinib)

DCC-2036 (Rebastinib)

DCC-2036 is a unique switch-pocket, non-ATP competitive (allosteric) inhibitor with IC50 at low nanomolar concentration against a number of tyrosine kinases including FLT3 (1.7 nM), TRKA (7.0 nM), TIE-2 (2.7 nM) and BCR-ABL (2.0 nM). DCC-2036 has shown promising activity in a phase I/II clinical trial in chronic myeloid leukemia (CML), where plasma concentrations of 350 nM of DCC-2036 have been safely achieved. DCC-2036 has induced clinical and molecular remissions in patients with TKI-resistant CML expressing the ‘gate-keeper’ T315I BCR-ABL mutation, as well as demonstrated activity against mutations that cause BCR-ABL conformational escape resistant.

Catalog NO:	CT-DCC20
Synonym:	Rebastinib
CAS NO:	1020172-07-9
Mol. Formula:	C₃₀H₂₈FN₇O₃
MW:	553.59

** Please ask for quote for other quantities. In stock, prompt..

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NO	Size	Price	In Stock	Quantity
1	10 mg	$90.00	YES
2	50 mg	$220.00	YES
3	100 mg	$380.00	YES

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Solubility : Soluble in DMSO

Storage : Store at 0 °C (short term), -20 °C (long term), desiccated

Purity : >99% (HPLC)

Original QC Data : ¹HNMR, HPLC and MS

Please Pick Batch NO:

DCC-2036, Current Lot, COA

1. W. W. Chan, et al., Cancer Cell. April 12, 2011; 19, 556-568

2. C. A. Eide, et al., Cancer Res. 2011 May 1; 71(9): 3189–3195.

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