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Home > Kinase Inhibitors > ErbB > Dacomitinib

Dacomitinib

Dacomitinib (PF-00299804) is a second-generation irreversible pan-erbB receptor tyrosine kinase inhibitor currently in clinical trials. It is believed to irreversibly inhibit erbB tyrosine kinase activity through binding at the ATP site and covalent modification of nucleophilic cysteine residues in the catalytic domains of erbB family members

Catalog NO:	CT-DACO
Synonym:	PF-00299804
CAS NO:	1042385-75-0 (Hydrate) 1110813-31-4 (Anhydrous)
Mol. Formula:	C₂₄H₂₅ClFN₅O₂ ∙ H₂O
MW:	488

** In vivo grade material. Monohydrate, validated by a spot-on quantitative elemental analysis. Bulk. Prompt

Pricing and OrderingTechnical Data

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NO	Size	Price	In Stock	Quantity
1	50 mg	$100.00	YES
2	100 mg	$160.00	YES
3	200 mg	$260.00	YES
4	500 mg	$480.00	YES

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Solubility : In DMSO

Storage : Store at 0°C (short term), -20°C (long term), desiccated.

Purity : >99% (HPLC at 214 and 254 nm)

Original QC Data : HPLC-MS, ¹HNMR, and Quantitative Elemental Analysis

Please Pick Batch NO:

Dacomitinib, Lot 01, Certificate of Analysis.pdf
Dacomitinib, Lot 01, Visual Appearance.pdf

1. J. A. Engelman, et al., PF00299804, an irreversible pan-ERBB inhibitor, is effective in lung cancer models with EGFR and ERBB2 mutations that are resistant to gefitinib. Cancer Res. 2007 Dec 15;67(24):11924-32

2. A. J. Gonzales, et al., Antitumor activity and pharmacokinetic properties of PF-00299804, a second-generation irreversible pan-erbB receptor tyrosine kinase inhibitor, Mol Cancer Ther. 2008 Jul;7(7):1880-9.

3. P. A. Jänne, et al., Phase I dose-escalation study of the pan-HER inhibitor, PF299804, in patients with advanced malignant solid tumors, Clin Cancer Res. 2011 Mar 1;17(5):1131-9. Epub 2011 Jan 10

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