Welcome visitor Log In - or - Register
(
0 items /
$0.00
)
View Cart
Check Out
four ways
Quick Search:
Skip Navigation LinksHome > Cell Cycle Modulators > SMAC Mimics and Inhibitors of IAP > AZD5582
AZD5582
AZD5582 is a cell permeable, novel class of dimeric SMAC mimetic designed to mimick the AVPI motif of SMAC. It is a potent and selective inhibitor of X-linked (XIAP) and cellular (cIAP) inhibitor of apoptosis protein with IC50 values of 15, 15 and 21 nM for XIAP, cIAP1 and cIAP2, respectively. At nanomolar concentrations AZD5582 causes extensive degradation of cIAP-1 and cIAP-2, and induces apoptosis in MDA-MB-231 breast cancer cells. It causes substantial tumor regressions following two weekly doses of 3.0 mg/kg in MDA-MB-231 xenograft-bearing mice.
Catalog NO: CT-A5582
Synonym:
CAS NO: 1258392-53-8
Mol. Formula: C58H78N8O8 ∙ 2HCl ∙ 2.5H2O
MW: 1133.3
** in vivo Quality Material, 99% purity by HPLC. Dihydrochloride, validated by a high-precision Quantitative elemental analysis. Water-soluble. Bulk stock. Same day shipping.
Northeast Business Center, 7301 E. 90th Street, Suite 117,Indianapolis, IN 46256, USA;
Tel: 317-598-0828, Toll-free: 1-877-343-6578 (US and Canada only);Fax: 317-598-0835; info@chemietek.com
Copyright © 2014 Chemietek. All Rights Reserved.