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Home > Kinase Inhibitors > CDK (Cyclin-dependent Kinase) > AZD4573 (AZD-4573)

AZD4573 (AZD-4573)

AZ4573 is a potent inhibitor of CDK9 with a biochemical IC50 of <3 nM, highly selective (>10 fold) against all other CDKs and kinases. AZD4573 rapidly induces cell death in hematological tumor models (both in vitro and in vivo) through depletion of Mcl-1 (ref. 1).

Catalog NO:	CT-A4573
Synonym:
CAS NO:	2057509-72-3
Mol. Formula:	C22H28ClN5O2
MW:	429.9

** in vivo Quality Material. 99.5-99.9% by achiral and chiral HPLCs (attached). Hemihydrate, validated by a spot-on quantitative elemental analysis. Bulk (Pls Ask quotes for 0.2, 0.5, 1.0G). Same day shipping.

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NO	Size	Price	In Stock	Quantity
1	5 mg	$160.00	YES
2	10 mg	$225.00	YES
3	50 mg	$750.00	YES
4	100 mg	$1,290.00	YES

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Solubility : Refer to Certificate of Analysis

Storage : Refer to Certificate of Analysis

Purity : >99.5% Pure by Achiral and Chiral HPLCs

Original QC Data : Achiral and Chiral HPLCs, MS, NMR, and Quantitative Elemental analysis Report

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AZD4573, Lot 01, Certificate of Analysis.pdf
AZD4573, Lot 01, Visual Appearance.pdf

1. J. Cidado, et al, AZD4573, a novel CDK9 inhibitor, rapidly induces cell death in hematological tumor models through depletion of Mcl1 [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl): Abstract nr 310.

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