AV-951 (Tivozanib) - Chemietek

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Home > Kinase Inhibitors > VEGFR > AV-951 (Tivozanib)

AV-951 (Tivozanib)

A potent, selective and orally active inhibitor of VEGFRs 1, 2 and 3, currently in clinical trial.

Catalog NO:	CT-AV951
Synonym:	Tivozanib
CAS NO:	475108-18-0
Mol. Formula:	C₂₂H₁₉ClN₄O₅
MW:	454.85

** Please ask for quote for other quantities. Ship within 1 day.

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NO	Size	Price	In Stock	Quantity
1	10 mg	$130.00	YES
2	50 mg	$400.00	YES
3	100 mg	$680.00	YES

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Solubility : Soluble in DMSO

Storage : Store at 0°C (short term), -20°C (long term), desiccated

Purity : 99% (HPLC)

Original QC Data : LC/MS, ¹HNMR

There is no COA file for this product

1. Taguchi E, Nakamura K, Miura T, Shibuya M, Isoe T. Anti-tumor activity and tumor vessel normalization by the vascular endothelial growth factor receptor tyrosine kinase inhibitor KRN951 in a rat peritoneal disseminated tumor model. Cancer Sci. 2008 Mar;99(3):623-30.

2. Nakamura K, Taguchi E, Miura T, Yamamoto A, Takahashi K, Bichat F, Guilbaud N, Hasegawa K, Kubo K, Fujiwara Y, Suzuki R, Kubo K, Shibuya M, Isae T. KRN951, a highly potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, has antitumor activities and affects functional vascular properties. Cancer Res. 2006 Sep 15;66(18):9134-42.

3. Murakami M, Iwai S, Hiratsuka S, Yamauchi M, Nakamura K, Iwakura Y, Shibuya M. Signaling of vascular endothelial growth factor receptor-1 tyrosine kinase promotes rheumatoid arthritis through activation of monocytes/macrophages. Blood. 2006 Sep 15;108(6):1849-56.

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