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Home > IDH (Isocitrate Dehydrogenase) Inhibitors > Mutant-IDH2 Inhibitor > AG-221 (Enasidenib)

AG-221 (Enasidenib)

AG-221 (Enasidenib) is a first-in-class, orally available, selective, potent inhibitor of mutant IDH2 (Isocitrate dehydrogenase type 2). It specifically inhibits IDH2 in the mitochondria, blocking the formation of oncometabolite 2-hydroxyglutarate (2HG). In in vitro studies, AG-221 reduced 2-HG levels by >90%, reversed histone and DNA hypermethylation, and induced cellular differentiation in leukemia cell models.

Catalog NO:	CT-AG221
Synonym:	Enasidenib, CC-90007
CAS NO:	1446502-11-9
Mol. Formula:	C19H17F6N7O
MW:	473.4

** 99.9% Purity. in vivo Grade Quality. Snow-white powder. Clean and impeccable (see attached QC Docs), with a spot-on Microanalysis. Bulk stock! Same day shipping.

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NO	Size	Price	In Stock	Quantity
1	10 mg	$80.00	YES
2	50 mg	$150.00	YES
3	100 mg	$230.00	YES
4	200 mg	$380.00	YES

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Solubility : Refer to Certificate

Storage : Refer to Certificate

Purity : >99.5% by HPLC at 214 and 254 nm

Original QC Data : HPLC-MS, 1H-NMR and Quantitative Elemental Analysis Report

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AG-221, Lot 01, Certificate of Analysis.pdf
AG-221, Lot 01, Appearance (color).pdf

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